CDK3 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CDK3	LHX4
Description		cyclin dependent kinase 3	LIM homeobox 4
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GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Population Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		41 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS1B CKS2 E2F1 E2F2 E2F3 FOXJ1 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NAP1L1 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63	53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76
Entrez ID		1018	89884
HPRD ID		00446	03686
Ensembl ID		ENSG00000250506	ENSG00000121454
Uniprot IDs		Q00526	A0A0S2Z5S4 Q969G2
PDB IDs		1LFN	5HOD
Enriched GO Terms of Interacting Partners?
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