DNAJA3 and RNF34

Data Source:
HPRD (two hybrid)

		DNAJA3	RNF34
Description		DnaJ heat shock protein family (Hsp40) member A3	ring finger protein 34
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Extrinsic Component Of Plasma Membrane Neuromuscular Junction Intracellular Membrane-bounded Organelle Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Nuclear Body Nuclear Speck
	Molecular Function	Protein Binding ATP Binding Hsp70 Protein Binding GTPase Regulator Activity Metal Ion Binding Unfolded Protein Binding	P53 Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitochondrial DNA Replication Protein Folding Activation-induced Cell Death Of T Cells Mitochondrion Organization Small GTPase Mediated Signal Transduction Cell Aging Negative Regulation Of Cell Population Proliferation Response To Heat T Cell Differentiation In Thymus Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Skeletal Muscle Acetylcholine-gated Channel Clustering	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways			Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Immature fraction of reticulocytes ( 32888494) Schizophrenia ( 28991256) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		44 interacting genes: ATXN1 BRCA1 C2CD6 CARM1 CIDEB COIL CYSRT1 FAM131C FAM214B FBXO7 FOSL2 FRMD6 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS LAMTOR5 MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 PTEN RAD51 RASA1 RELA RNF34 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22	10 interacting genes: APP APPBP2 DNAJA3 MAVS NOD1 PHF7 TRIM23 UBE2D2 UBE2F UBE2H
Entrez ID		9093	80196
HPRD ID		09758	10509
Ensembl ID		ENSG00000103423	ENSG00000170633
Uniprot IDs		B3KM81 Q53G26 Q59E88 Q96EY1	A0A087WTM5 Q969K3
PDB IDs		2CTT 2DN9 6IWS
Enriched GO Terms of Interacting Partners?
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