RNF34 and DNAJA3

Data Source:
HPRD (two hybrid)

		RNF34	DNAJA3
Description		ring finger protein 34	DnaJ heat shock protein family (Hsp40) member A3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Nuclear Body Nuclear Speck	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Extrinsic Component Of Plasma Membrane Neuromuscular Junction Intracellular Membrane-bounded Organelle Postsynaptic Membrane
	Molecular Function	P53 Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding	Protein Binding ATP Binding Hsp70 Protein Binding GTPase Regulator Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Negative Regulation Of Transcription By RNA Polymerase II Mitochondrial DNA Replication Protein Folding Activation-induced Cell Death Of T Cells Mitochondrion Organization Small GTPase Mediated Signal Transduction Cell Aging Negative Regulation Of Cell Population Proliferation Response To Heat T Cell Differentiation In Thymus Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Erectile dysfunction ( 30583798) Immature fraction of reticulocytes ( 32888494) Schizophrenia ( 28991256) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		10 interacting genes: APP APPBP2 DNAJA3 MAVS NOD1 PHF7 TRIM23 UBE2D2 UBE2F UBE2H	44 interacting genes: ATXN1 BRCA1 C2CD6 CARM1 CIDEB COIL CYSRT1 FAM131C FAM214B FBXO7 FOSL2 FRMD6 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS LAMTOR5 MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 PTEN RAD51 RASA1 RELA RNF34 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22
Entrez ID		80196	9093
HPRD ID		10509	09758
Ensembl ID		ENSG00000170633	ENSG00000103423
Uniprot IDs		A0A087WTM5 Q969K3	B3KM81 Q53G26 Q59E88 Q96EY1
PDB IDs			2CTT 2DN9 6IWS
Enriched GO Terms of Interacting Partners?
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