TH and TYSND1

Number of citations of the paper that reports this interaction (PMID 22002062)
8

Data Source:
BioGRID (enzymatic study)

		TH	TYSND1
Gene Name		tyrosine hydroxylase	trypsin domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon	Peroxisome Membrane
	Molecular Function	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding	Protease Binding Serine-type Endopeptidase Activity Identical Protein Binding
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Organ Morphogenesis Response To Zinc Ion Multicellular Organismal Aging Response To Activity Synaptic Vesicle Amine Transport Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Cellular Nitrogen Compound Metabolic Process Social Behavior Cellular Response To Drug Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Small Molecule Metabolic Process Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Oxidation-reduction Process Cellular Response To Manganese Ion Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus	Proteolysis Protein Processing Regulation Of Fatty Acid Beta-oxidation Protein Homooligomerization
Pathways		Amine-derived hormones Catecholamine biosynthesis Metabolism of amino acids and derivatives
Drugs		L-Phenylalanine L-Tyrosine Tetrahydrobiopterin Metyrosine Meta-Tyrosine 7,8-Dihydrobiopterin
Diseases
GWAS		Prostate cancer ( 19767753)
Protein-Protein Interactions		12 interactors: CAMK2G CDK11B CSNK2A1 MAPK1 MAPK3 MAPKAPK2 PRKACA RPS6KA5 SNCA TYSND1 YWHAB YWHAZ	2 interactors: ACOX1 TH
Entrez ID		7054	219743
HPRD ID		01865	15593
Ensembl ID		ENSG00000180176	ENSG00000156521
Uniprot IDs		P07101 P78428 Q0PWM2 Q0PWM3	Q2T9J0
PDB IDs		2XSN
Enriched GO Terms of Interacting Partners?		Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Innate Immune Response Immune Response Phosphate-containing Compound Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Heat Defense Response Apoptotic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Cell Death Death Epidermal Growth Factor Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway ERBB Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Cytokine Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Heat MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Toll-like Receptor 3 Signaling Pathway Regulation Of Intracellular Transport Protein Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity MAPK Cascade Positive Regulation Of Phosphorylation Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Immune System Process Response To Interleukin-1 Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Transferase Activity Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor Signaling Pathway	Dopamine Biosynthetic Process From Tyrosine Epinephrine Biosynthetic Process Fatty Acid Metabolic Process Synaptic Vesicle Amine Transport Phytoalexin Metabolic Process Terpene Metabolic Process Isoquinoline Alkaloid Metabolic Process Epinephrine Metabolic Process Positive Regulation Of Cholesterol Homeostasis Response To Pyrethroid Cellular Response To Manganese Ion Norepinephrine Biosynthetic Process Response To Ether Amine Transport Monocarboxylic Acid Metabolic Process Response To Water Deprivation Cellular Response To Nicotine Circadian Sleep/wake Cycle Phthalate Metabolic Process Response To Herbicide Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Alkaloid Metabolic Process Tyrosine Metabolic Process Peroxisome Fission Dopamine Biosynthetic Process Norepinephrine Metabolic Process Toxin Metabolic Process Synaptic Transmission, Dopaminergic Sexual Reproduction Glycoside Metabolic Process Neurotransmitter Biosynthetic Process Chemical Homeostasis Circadian Behavior Regulation Of Cholesterol Homeostasis Response To Insecticide Response To Manganese Ion Rhythmic Behavior Catecholamine Biosynthetic Process Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Response To Immobilization Stress Reproduction Dopamine Metabolic Process Neurotransmitter Metabolic Process Organic Acid Metabolic Process Eating Behavior Prostaglandin Metabolic Process Very Long-chain Fatty Acid Metabolic Process Response To Corticosterone
Tagcloud ?		adrenal avian becomes catecholamine catecholaminergic chromaffin coexpressed coexpression differs embryo galanin ganglia ganglion hydroxylase immunocytochemistry immunoreactivities immunoreactivity intensely neuroactive paravertebral primordia principal repertoire sif somatostatin substances sympathetic sympathoadrenal sympathoblasts synthesizing
Tagcloud (Difference) ?		adrenal avian becomes catecholamine catecholaminergic chromaffin coexpressed coexpression differs embryo galanin ganglia ganglion hydroxylase immunocytochemistry immunoreactivities immunoreactivity intensely neuroactive paravertebral primordia principal repertoire sif somatostatin substances sympathetic sympathoadrenal sympathoblasts synthesizing
Tagcloud (Intersection) ?