CD2 and CD5

Number of citations of the paper that reports this interaction (PMID 10510361)
3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD2	CD5
Gene Name		CD2 molecule	CD5 molecule
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Activity Receptor Binding Protein Binding Protein Homodimerization Activity	Receptor Activity Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Blood Coagulation Single Organismal Cell-cell Adhesion Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion	Receptor-mediated Endocytosis Cell Recognition Cell Proliferation T Cell Costimulation Apoptotic Signaling Pathway
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Alpha-D-Mannose
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		19 interactors: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1	22 interactors: CAMK2D CBL CD2 CD247 CD27 CD4 CD6 CD72 CD79A CD79B CSNK2A1 DYNLT3 FYN HNRNPU LCK PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70
Entrez ID		914	921
HPRD ID		01750	01078
Ensembl ID		ENSG00000116824	ENSG00000110448
Uniprot IDs		P06729 Q53F96	P06127
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	2JA4 2JOP 2JP0 2OTT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Immune System Process Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Defense Response To Virus Innate Immune Response Cell Migration Locomotion Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Cell Motility Signal Transduction Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Response To Wounding Signaling Lymphocyte Activation Response To Stimulus Cell Communication Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Positive Regulation Of Gamma-delta T Cell Differentiation Leukocyte Activation Leukocyte Migration Regulation Of Immune Response Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Single Organismal Cell-cell Adhesion Response To Stress Viral Process T Cell Aggregation T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Aggregation	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Immune System Process Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion T Cell Costimulation Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Signal Transduction B Cell Receptor Signaling Pathway Immune Response Signal Transduction Platelet Activation Positive Regulation Of T Cell Activation T Cell Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Innate Immune Response Signaling Leukocyte Migration Cell Communication Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Blood Coagulation Hemostasis Locomotion Leukocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Stimulus Response To Fibroblast Growth Factor Movement Of Cell Or Subcellular Component Protein Autophosphorylation Regulation Of Body Fluid Levels
Tagcloud ?		2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	bmt cd11b cd11c cd19 cd45 cytometric cytopenias deferral definitive dilemma gating hairy hcl hodgkin immunophenotyping maturing mdf morphologic multidimensional myeloblast myelodysplasia pancytopenia phenotyping presumptive refined reside scatter scheme unexplained
Tagcloud (Difference) ?		2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	bmt cd11b cd11c cd19 cd45 cytometric cytopenias deferral definitive dilemma gating hairy hcl hodgkin immunophenotyping maturing mdf morphologic multidimensional myeloblast myelodysplasia pancytopenia phenotyping presumptive refined reside scatter scheme unexplained
Tagcloud (Intersection) ?