CD44 and ANK1

Number of citations of the paper that reports this interaction (PMID 15051494)
27

Data Source:
BioGRID (unspecified method)
HPRD (in vivo, in vitro)

		CD44	ANK1
Gene Name		CD44 molecule (Indian blood group)	ankyrin 1, erythrocytic
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Macrophage Migration Inhibitory Factor Receptor Complex Extracellular Vesicular Exosome	Nucleus Cytosol Cytoskeleton Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma Cortical Cytoskeleton M Band Sarcolemma Postsynaptic Membrane
	Molecular Function	Hyalurononglucosaminidase Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Spectrin Binding ATPase Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Wound Healing Involved In Inflammatory Response Carbohydrate Metabolic Process Cell-matrix Adhesion Blood Coagulation Pathogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Porphyrin-containing Compound Biosynthetic Process Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Axon Guidance Positive Regulation Of Organelle Organization Monovalent Inorganic Cation Transport Maintenance Of Epithelial Cell Apical/basal Polarity Erythrocyte Development Iron Ion Homeostasis Protein Targeting To Plasma Membrane
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Hyaluronan uptake and degradation Interferon gamma signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Interferon Signaling Defective CHST3 causes SEDCJD Cytokine Signaling in Immune system Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Cell surface interactions at the vascular wall MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Interaction between L1 and Ankyrins CHL1 interactions Axon guidance Neurofascin interactions NrCAM interactions L1CAM interactions
Drugs		Hyaluronan
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Vitiligo ( 22561518)	Glycated hemoglobin levels ( 20858683) Pulmonary function decline ( 22424883) Type 2 diabetes ( 22456796)
Protein-Protein Interactions		39 interactors: ANK1 ARHGEF1 ARHGEF12 CD4 CD74 COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 ERBB4 EZR FGF2 FN1 FYN GARS HBEGF HMMR IGFBP3 LCK MADCAM1 MMP1 MMP7 MMP9 MSN NF2 PKN1 SELE SPP1 SRC SRGN TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	18 interactors: BLOC1S6 CD44 EPB42 ITPR3 KCTD6 L1CAM NBPF3 NEDD8 NFASC OBSCN RHAG SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN
Entrez ID		960	286
HPRD ID		00115	01693
Ensembl ID		ENSG00000026508	ENSG00000029534
Uniprot IDs		P16070	B3KX39 P16157
PDB IDs		1POZ 1UUH 2I83	1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Wound Healing Immune System Process Leukocyte Migration Regulation Of Cellular Component Movement Response To Wounding Anatomical Structure Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway System Development Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Motility Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Locomotion Cell Differentiation Regulation Of Cell Migration Multicellular Organismal Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Extracellular Matrix Disassembly Tissue Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Organ Development Platelet Activation Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Cell Motility Response To Stress Cell Adhesion Neurogenesis Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Nervous System Development Single Organismal Cell-cell Adhesion	Cell Development Anatomical Structure Morphogenesis Axon Guidance Movement Of Cell Or Subcellular Component Neuron Projection Development Locomotion Axonogenesis Anatomical Structure Development Bicarbonate Transport Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Response To Growth Factor Cell Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Developmental Process Neuron Differentiation Cell Morphogenesis Involved In Differentiation Actin Filament Capping Cell Projection Organization Blood Coagulation Multicellular Organismal Development Hemostasis Negative Regulation Of Actin Filament Depolymerization Response To External Stimulus Cell Projection Morphogenesis Regulation Of Actin Filament Depolymerization Cell Part Morphogenesis Chemical Homeostasis System Development Negative Regulation Of Actin Filament Polymerization Homeostatic Process Cellular Chemical Homeostasis Negative Regulation Of Protein Polymerization Ion Homeostasis Regulation Of Body Fluid Levels Negative Regulation Of Protein Complex Disassembly Wound Healing Generation Of Neurons Hemopoiesis Regulation Of Protein Depolymerization Nervous System Development Neurogenesis Regulation Of Protein Complex Disassembly Response To Wounding Cellular Homeostasis Immune System Development
Tagcloud ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Difference) ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Intersection) ?