CD44 and COL14A1

Number of citations of the paper that reports this interaction (PMID 8986622)
9

Data Source:
HPRD (in vitro)

		CD44	COL14A1
Gene Name		CD44 molecule (Indian blood group)	collagen, type XIV, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Macrophage Migration Inhibitory Factor Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Collagen Type XIV Trimer Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Hyalurononglucosaminidase Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Extracellular Matrix Structural Constituent Collagen Binding Protein Binding, Bridging Poly(A) RNA Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Wound Healing Involved In Inflammatory Response Carbohydrate Metabolic Process Cell-matrix Adhesion Blood Coagulation Pathogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Ventricular Cardiac Muscle Tissue Development Single Organismal Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Hyaluronan uptake and degradation Interferon gamma signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Interferon Signaling Defective CHST3 causes SEDCJD Cytokine Signaling in Immune system Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Cell surface interactions at the vascular wall MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix
Drugs		Hyaluronan
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Vitiligo ( 22561518)
Protein-Protein Interactions		39 interactors: ANK1 ARHGEF1 ARHGEF12 CD4 CD74 COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 ERBB4 EZR FGF2 FN1 FYN GARS HBEGF HMMR IGFBP3 LCK MADCAM1 MMP1 MMP7 MMP9 MSN NF2 PKN1 SELE SPP1 SRC SRGN TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	3 interactors: APP CD44 DCN
Entrez ID		960	7373
HPRD ID		00115	00379
Ensembl ID		ENSG00000026508	ENSG00000187955
Uniprot IDs		P16070	Q05707
PDB IDs		1POZ 1UUH 2I83
Enriched GO Terms of Interacting Partners?		Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Wound Healing Immune System Process Leukocyte Migration Regulation Of Cellular Component Movement Response To Wounding Anatomical Structure Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway System Development Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Motility Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Locomotion Cell Differentiation Regulation Of Cell Migration Multicellular Organismal Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Extracellular Matrix Disassembly Tissue Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Organ Development Platelet Activation Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Cell Motility Response To Stress Cell Adhesion Neurogenesis Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Nervous System Development Single Organismal Cell-cell Adhesion	Extracellular Matrix Organization Extracellular Structure Organization Glycosaminoglycan Catabolic Process Wound Healing Response To Wounding Extracellular Matrix Disassembly Glycosaminoglycan Metabolic Process Reproductive Process Pathogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Synaptic Growth At Neuromuscular Junction Positive Regulation Of Monocyte Aggregation Monocyte Aggregation Collateral Sprouting In Absence Of Injury Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Kidney Development Renal System Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Processing Urogenital System Development Regulation Of Endopeptidase Activity Wound Healing Involved In Inflammatory Response Axon Choice Point Recognition Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Small Molecule Metabolic Process Anatomical Structure Morphogenesis Neuron Remodeling Positive Regulation Of Heterotypic Cell-cell Adhesion Reproductive Structure Development Regulation Of Cellular Ketone Metabolic Process Reproductive System Development Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Dermatan Sulfate Proteoglycan Biosynthetic Process Hyaluronan Catabolic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Tagcloud ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	cdkn2a clusters cpg dedifferentiated dmrt2 fbln2 humanmethylation27 hypermethylated hypermethylation hypomethylation infinium integrating inverse liposarcoma liposarcomas methylation myxoid neoplastic nnat partitioned pleomorphic pyroxd2 represented sarcomas showing soft speg usefulness znf217
Tagcloud (Difference) ?		acute aml blastic cml elevated hematologic immunosorbent implications kda leukemia lymphoid marker ml monitoring monoclonal myelodysplastic myeloid nearly neoplasias ng phases reached remission scd44 serum slightly soluble syndromes volunteers	cdkn2a clusters cpg dedifferentiated dmrt2 fbln2 humanmethylation27 hypermethylated hypermethylation hypomethylation infinium integrating inverse liposarcoma liposarcomas methylation myxoid neoplastic nnat partitioned pleomorphic pyroxd2 represented sarcomas showing soft speg usefulness znf217
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