CAMK2N2 and CAMK2A

Number of citations of the paper that reports this interaction (PMID 9724800)
60

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CAMK2N2	CAMK2A
Gene Name		calcium/calmodulin-dependent protein kinase II inhibitor 2	calcium/calmodulin-dependent protein kinase II alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways			Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: ARHGAP32 CAMK2A CAMK2B LNX1	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		94032	815
HPRD ID		16377	06532
Ensembl ID		ENSG00000163888	ENSG00000070808
Uniprot IDs		Q96S95	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Regulation Of Neuronal Synaptic Plasticity Cellular Response To Heat Response To Heat Peptidyl-serine Phosphorylation Interferon-gamma-mediated Signaling Pathway Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Plasticity Response To Interferon-gamma Activation Of Meiosis Involved In Egg Activation Response To Temperature Stimulus Regulation Of Calcium Ion Transport Protein Autophosphorylation Activation Of Meiosis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Synaptic Transmission Calcium Ion Transport Regulation Of Synaptic Transmission, Cholinergic Regulation Of Skeletal Muscle Adaptation Regulation Of Synapse Structural Plasticity Cytokine-mediated Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Meiotic Nuclear Division Egg Activation Regulation Of Synapse Maturation Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Synaptic Transmission Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Ion Transport Positive Regulation Of Dendritic Spine Development Mitotic Cell Cycle Process Response To Cytokine Regulation Of Long-term Neuronal Synaptic Plasticity Response To Ischemia Regulation Of Mitochondrial Membrane Permeability Regulation Of Dendritic Spine Morphogenesis Mitotic Cell Cycle Regulation Of Membrane Permeability Positive Regulation Of Dendrite Morphogenesis Innate Immune Response Metal Ion Transport	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?			acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?			acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?