CAMK2A and CDK5R2

Number of citations of the paper that reports this interaction (PMID 12223541)
22

Data Source:
HPRD (two hybrid, in vitro)

		CAMK2A	CDK5R2
Gene Name		calcium/calmodulin-dependent protein kinase II alpha	cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane	Cytoplasm Plasma Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity	Lipid Binding Cyclin-dependent Protein Kinase 5 Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB	4 interactors: ACTB ACTN1 CAMK2A CDK5
Entrez ID		815	8941
HPRD ID		06532	04790
Ensembl ID		ENSG00000070808	ENSG00000171450
Uniprot IDs		A8K161 Q7LDD5 Q8IWE0 Q9UQM7	Q13319
PDB IDs		2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Adherens Junction Organization Response To Wounding Peptidyl-serine Phosphorylation Membrane Organization Regulation Of Synaptic Plasticity Cell-matrix Adhesion Organelle Organization Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Response To Stress Protein Autophosphorylation Negative Regulation Of Synaptic Plasticity Cell-substrate Adhesion Cell Adhesion Protein Localization To Tight Junction Serine Phosphorylation Of STAT3 Protein Vesicle-mediated Transport Regulation Of Apoptotic Process Serine Phosphorylation Of STAT Protein Regulation Of Synaptic Transmission Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Death Exocytosis Regulation Of Synaptic Vesicle Recycling Protein Localization To Cell Junction Axon Guidance Cellular Component Assembly Transport Synaptic Transmission, Dopaminergic Establishment Of Localization In Cell Behavioral Response To Cocaine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization Secretion By Cell Axonogenesis Positive Regulation Of Calcium Ion-dependent Exocytosis Actin Crosslink Formation Corpus Callosum Development Protein Localization To Synapse Axon Development Receptor Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process
Tagcloud ?		acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta	aids ak1 biosynthesis cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital
Tagcloud (Difference) ?		acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta	aids ak1 biosynthesis cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital
Tagcloud (Intersection) ?