CAMK2N2 and CAMK2B

Number of citations of the paper that reports this interaction (PMID 9724800)
60

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CAMK2N2	CAMK2B
Gene Name		calcium/calmodulin-dependent protein kinase II inhibitor 2	calcium/calmodulin-dependent protein kinase II beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Spindle Midzone
	Molecular Function	Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity	G1/S Transition Of Mitotic Cell Cycle Inhibitory G-protein Coupled Receptor Phosphorylation Protein Phosphorylation Calcium Ion Transport Signal Transduction Synaptic Transmission Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Synaptic Transmission, Cholinergic Cellular Response To Heat Response To Cadmium Ion Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Activation Of Meiosis Involved In Egg Activation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Metabolic syndrome ( 22399527)
Protein-Protein Interactions		4 interactors: ARHGAP32 CAMK2A CAMK2B LNX1	37 interactors: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB
Entrez ID		94032	816
HPRD ID		16377	12127
Ensembl ID		ENSG00000163888	ENSG00000058404
Uniprot IDs		Q96S95	A4D2J9 Q13554
PDB IDs			3BHH
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Regulation Of Neuronal Synaptic Plasticity Cellular Response To Heat Response To Heat Peptidyl-serine Phosphorylation Interferon-gamma-mediated Signaling Pathway Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Plasticity Response To Interferon-gamma Activation Of Meiosis Involved In Egg Activation Response To Temperature Stimulus Regulation Of Calcium Ion Transport Protein Autophosphorylation Activation Of Meiosis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Synaptic Transmission Calcium Ion Transport Regulation Of Synaptic Transmission, Cholinergic Regulation Of Skeletal Muscle Adaptation Regulation Of Synapse Structural Plasticity Cytokine-mediated Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Meiotic Nuclear Division Egg Activation Regulation Of Synapse Maturation Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Synaptic Transmission Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Ion Transport Positive Regulation Of Dendritic Spine Development Mitotic Cell Cycle Process Response To Cytokine Regulation Of Long-term Neuronal Synaptic Plasticity Response To Ischemia Regulation Of Mitochondrial Membrane Permeability Regulation Of Dendritic Spine Morphogenesis Mitotic Cell Cycle Regulation Of Membrane Permeability Positive Regulation Of Dendrite Morphogenesis Innate Immune Response Metal Ion Transport	Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Membrane Depolarization Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transferase Activity Startle Response Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Retinoic Acid Receptor Signaling Pathway Neuromuscular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Regulation Of RNA Metabolic Process Learning Positive Regulation Of Metabolic Process Response To Stress Gene Expression Synaptic Transmission Cardiac Muscle Tissue Growth Regulation Of Erythrocyte Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Palmitic Acid Biosynthetic Process Peptidyl-cysteine S-trans-nitrosylation Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process System Development Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation
Tagcloud ?			1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
Tagcloud (Difference) ?			1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
Tagcloud (Intersection) ?