GRAP2 and PRPH2

Number of citations of the paper that reports this interaction (PMID 11641407)
44

Data Source:
HPRD (in vitro)

		GRAP2	PRPH2
Gene Name		GRB2-related adaptor protein 2	peripherin 2 (retinal degeneration, slow)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol	Integral Component Of Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response T Cell Receptor Signaling Pathway	Cell Adhesion Visual Perception Response To Low Light Intensity Stimulus Retina Development In Camera-type Eye
Pathways		DAP12 interactions Generation of second messenger molecules Costimulation by the CD28 family CD28 co-stimulation FCERI mediated MAPK activation Signaling by SCF-KIT DAP12 signaling TCR signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: BEND5 BLNK CCNDBP1 CD28 CSF1R ERBB2 FASLG GAB1 GAB2 GAB3 GFAP GNB2L1 HNRNPK KHDRBS1 KIT KRTAP4-12 LAT LAX1 LCP2 MAP4K1 PRPH2 RBPMS SHB SHC1 SOS2 SPRY2 STAMBP UBC USP8 YWHAE ZBTB7B	4 interactors: CNGB1 GRAP2 PRPH ROM1
Entrez ID		9402	5961
HPRD ID		05156	01553
Ensembl ID		ENSG00000100351	ENSG00000112619
Uniprot IDs		B7Z8E3 B7Z8F8 F5H548 O75791 Q6FI14	P23942
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Response To Growth Factor Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Phosphatidylinositol-mediated Signaling Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Immune Response Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Stimulus Regulation Of Phosphorylation	Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Retina Development In Camera-type Eye Neurological System Process Response To Low Light Intensity Stimulus Response To Light Stimulus Camera-type Eye Development Eye Development Response To Light Intensity Response To Radiation Camera-type Eye Photoreceptor Cell Differentiation Detection Of Light Stimulus Involved In Visual Perception Protein Heterotetramerization Sensory Organ Development Retina Vasculature Development In Camera-type Eye Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Photoreceptor Cell Maintenance Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process
Tagcloud ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	accelerated adenoassociated augmentation blinding carrying degenerations electroretinogram incurable inherited insults ipd ipds neuroprotective p347s photoreceptor promise prosurvival prs r26 raav rds retinal rho rosa26 scotopic stat3 tg y705f
Tagcloud (Difference) ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	accelerated adenoassociated augmentation blinding carrying degenerations electroretinogram incurable inherited insults ipd ipds neuroprotective p347s photoreceptor promise prosurvival prs r26 raav rds retinal rho rosa26 scotopic stat3 tg y705f
Tagcloud (Intersection) ?