GRAP2 and SPRY2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GRAP2	SPRY2
Gene Name		GRB2-related adaptor protein 2	sprouty homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol	Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Ruffle Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response T Cell Receptor Signaling Pathway	Establishment Of Mitotic Spindle Orientation Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		DAP12 interactions Generation of second messenger molecules Costimulation by the CD28 family CD28 co-stimulation FCERI mediated MAPK activation Signaling by SCF-KIT DAP12 signaling TCR signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System	Signaling by EGFR EGFR downregulation Signaling by FGFR in disease Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS			Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) Orofacial clefts ( 20023658 22863734) Type 2 diabetes ( 20862305)
Protein-Protein Interactions		31 interactors: BEND5 BLNK CCNDBP1 CD28 CSF1R ERBB2 FASLG GAB1 GAB2 GAB3 GFAP GNB2L1 HNRNPK KHDRBS1 KIT KRTAP4-12 LAT LAX1 LCP2 MAP4K1 PRPH2 RBPMS SHB SHC1 SOS2 SPRY2 STAMBP UBC USP8 YWHAE ZBTB7B	90 interactors: ADAMTSL4 AQP1 ATRIP C19orf66 CATSPER1 CBL CBLB CBLC CHRD CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 HEXIM2 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PTGER3 PTPN11 RAF1 RTFDC1 RUNX1T1 SDHB SEMA5B SH3KBP1 SIAH2 SPRY1 STK16 TCAF1 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587
Entrez ID		9402	10253
HPRD ID		05156	03916
Ensembl ID		ENSG00000100351	ENSG00000136158
Uniprot IDs		B7Z8E3 B7Z8F8 F5H548 O75791 Q6FI14	O43597
PDB IDs			3BUM 3OB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Response To Growth Factor Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Phosphatidylinositol-mediated Signaling Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Immune Response Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Stimulus Regulation Of Phosphorylation	Negative Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Keratinization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process Keratinocyte Differentiation Regulation Of Cell Activation Negative Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Cell Death System Development Death Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Developmental Process Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of T Cell Activation Cellular Response To Organic Substance Cell Differentiation Anatomical Structure Development Organ Development Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Epidermal Cell Differentiation Response To Growth Factor Protein Modification By Small Protein Conjugation Epithelium Development Regulation Of Apoptotic Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Kinase Activity Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Difference) ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Intersection) ?