GRAP2 and GAB3

Number of citations of the paper that reports this interaction (PMID 12773374)
30

Data Source:
HPRD (in vitro)

		GRAP2	GAB3
Gene Name		GRB2-related adaptor protein 2	GRB2-associated binding protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response T Cell Receptor Signaling Pathway	Macrophage Differentiation
Pathways		DAP12 interactions Generation of second messenger molecules Costimulation by the CD28 family CD28 co-stimulation FCERI mediated MAPK activation Signaling by SCF-KIT DAP12 signaling TCR signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: BEND5 BLNK CCNDBP1 CD28 CSF1R ERBB2 FASLG GAB1 GAB2 GAB3 GFAP GNB2L1 HNRNPK KHDRBS1 KIT KRTAP4-12 LAT LAX1 LCP2 MAP4K1 PRPH2 RBPMS SHB SHC1 SOS2 SPRY2 STAMBP UBC USP8 YWHAE ZBTB7B	8 interactors: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC
Entrez ID		9402	139716
HPRD ID		05156	06571
Ensembl ID		ENSG00000100351	ENSG00000160219
Uniprot IDs		B7Z8E3 B7Z8F8 F5H548 O75791 Q6FI14	A6NHF8 Q8WWW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Response To Growth Factor Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Phosphatidylinositol-mediated Signaling Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Immune Response Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Stimulus Regulation Of Phosphorylation	T Cell Costimulation Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Response To Peptide Platelet Activation Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune System Process Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Wound Healing Phagocytosis Positive Regulation Of Immune Response Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	adaptor angiogenesis binders biological consist date diversified docking effector effectors exclusively gab1 gab2 grb2 homology intensively link mediate motifs overview p85 phosphatidylinositol playing rtks sh2 shp2 special transducing
Tagcloud (Difference) ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	adaptor angiogenesis binders biological consist date diversified docking effector effectors exclusively gab1 gab2 grb2 homology intensively link mediate motifs overview p85 phosphatidylinositol playing rtks sh2 shp2 special transducing
Tagcloud (Intersection) ?