ACVRL1 and BAMBI

Number of citations of the paper that reports this interaction (PMID 19758997)
21

Data Source:
BioGRID (pull down)

		ACVRL1	BAMBI
Gene Name		activin A receptor type II-like 1	BMP and activin membrane-bound inhibitor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface Dendrite Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding	Frizzled Binding Type II Transforming Growth Factor Beta Receptor Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Heterooligomerization Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process	Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs		Adenosine triphosphate
Diseases
GWAS		Urate levels ( 23263486)	Preeclampsia ( 23551011)
Protein-Protein Interactions		12 interactors: ACVR2A BAMBI CSNK2B FKBP1A SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP	8 interactors: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B SEP15 SOX30 TGFBR1
Entrez ID		94	25805
HPRD ID		03181	05117
Ensembl ID		ENSG00000139567	ENSG00000095739
Uniprot IDs		E7EN07 P37023	Q13145
PDB IDs		2LCR 3MY0 4FAO
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Complex Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Binding Positive Regulation Of Ossification Positive Regulation Of Protein Import Into Nucleus Skeletal System Development Response To Cholesterol Signal Transduction By Phosphorylation Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Signal Transduction	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus In Utero Embryonic Development Response To Transforming Growth Factor Beta Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Peptidyl-threonine Phosphorylation Positive Regulation Of Signal Transduction Protein Phosphorylation Reproductive Process Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Sex Differentiation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Cell Differentiation Regulation Of Cartilage Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Tissue Development Positive Regulation Of Ossification Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Mesenchymal Cell Development Pathway-restricted SMAD Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Protein Phosphorylation Mesenchymal Cell Differentiation Pattern Specification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Pharyngeal System Development Embryo Development Positive Regulation Of Epithelial Cell Proliferation Single Organism Reproductive Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Activin Receptor Signaling Pathway
Tagcloud ?		a1cf activins ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 trim46 ube2q2 urate vegfa	95th bavaria bavarian breastfed chlorophenyl dde dibenzofurans dichloro hexachlorobenzene hrms mugl musks ngg ngkg ops organochlorine pcbs pcdds pcdfs perfluorinated perfluorooctane pfcs polychlorinated sulfonate tdi teq1998 teq1998g tolerable who1998
Tagcloud (Difference) ?		a1cf activins ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 trim46 ube2q2 urate vegfa	95th bavaria bavarian breastfed chlorophenyl dde dibenzofurans dichloro hexachlorobenzene hrms mugl musks ngg ngkg ops organochlorine pcbs pcdds pcdfs perfluorinated perfluorooctane pfcs polychlorinated sulfonate tdi teq1998 teq1998g tolerable who1998
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