CD9 and CD59

Number of citations of the paper that reports this interaction (PMID 1377690)
15

Data Source:
HPRD (in vitro)

		CD9	CD59
Gene Name		CD9 molecule	CD59 molecule, complement regulatory protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Vesicle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Vesicle Sarcolemma Compact Myelin Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding	Complement Binding Protein Binding
	Biological Process	Platelet Degranulation Movement Of Cell Or Subcellular Component Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Pathogenesis Response To Water Deprivation Oligodendrocyte Development Platelet Activation Paranodal Junction Assembly Multicellular Organism Reproduction	Cell Activation Negative Regulation Of Activation Of Membrane Attack Complex Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response
Pathways		Uptake and actions of bacterial toxins Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Fertilization Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Paclitaxel-induced neuropathy ( 23776197) Platelet counts ( 22139419)
Protein-Protein Interactions		22 interactors: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT PRKCA PTGFRN SERPINH1 TSPAN4 VKORC1	12 interactors: C8A C9 CD2 CD8A CD9 EGFR GNAI3 NCR1 NCR3 SLC6A8 SMAD4 SRC
Entrez ID		928	966
HPRD ID		00880	00117
Ensembl ID		ENSG00000010278
Uniprot IDs		B4DK09 P21926	E9PI80 P13987 Q6FHM9
PDB IDs			1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Immune System Process Regulation Of Protein Metabolic Process Learning Or Memory Cognition Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Proliferation Cell Migration Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Cell Migration Extracellular Matrix Organization Associative Learning Extracellular Structure Organization Locomotion Cell Motility Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Tissue Development Cell-substrate Adhesion Positive Regulation Of Endocytosis Leukocyte Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Single-organism Behavior Mesodermal Cell Differentiation Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling	Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Immune Response Defense Response Immune System Process Complement Activation, Alternative Pathway Positive Regulation Of Protein Transport Immune Response Membrane Organization Blood Coagulation Hemostasis Positive Regulation Of Immune System Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Cytolysis Single Organismal Cell-cell Adhesion Platelet Activation Regulation Of Complement Activation Regulation Of Body Fluid Levels Wound Healing Cell Adhesion Regulation Of Protein Transport Positive Regulation Of Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Establishment Of Protein Localization Leukocyte Mediated Immunity Adaptive Immune Response Response To Wounding Regulation Of Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transport Natural Killer Cell Activation Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Innate Immune Response Alkanesulfonate Metabolic Process Cytotoxic T Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Myeloid Dendritic Cell Activation Regulation Of Acute Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Positive Regulation Of Cytokine Secretion Regulation Of Protein Processing Positive Regulation Of Protein Import Into Nucleus Lymphocyte Activation
Tagcloud ?		accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Difference) ?		accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Intersection) ?