CD9 and TSPAN4

Number of citations of the paper that reports this interaction (PMID 9360996)
17

Data Source:
HPRD (in vivo)

		CD9	TSPAN4
Gene Name		CD9 molecule	tetraspanin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Vesicle Extracellular Vesicular Exosome	Plasma Membrane Focal Adhesion Integral Component Of Membrane Vesicle
	Molecular Function	Integrin Binding Protein Binding	Antigen Binding Integrin Binding
	Biological Process	Platelet Degranulation Movement Of Cell Or Subcellular Component Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Pathogenesis Response To Water Deprivation Oligodendrocyte Development Platelet Activation Paranodal Junction Assembly Multicellular Organism Reproduction	Protein Complex Assembly
Pathways		Uptake and actions of bacterial toxins Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Fertilization Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Paclitaxel-induced neuropathy ( 23776197) Platelet counts ( 22139419)
Protein-Protein Interactions		22 interactors: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT PRKCA PTGFRN SERPINH1 TSPAN4 VKORC1	8 interactors: CD46 CD81 CD9 CLDN11 ITGA3 ITGA6 ITGB1 NOTCH2NL
Entrez ID		928	7106
HPRD ID		00880	04033
Ensembl ID		ENSG00000010278	ENSG00000214063
Uniprot IDs		B4DK09 P21926	A8MVV6 O14817
PDB IDs
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Immune System Process Regulation Of Protein Metabolic Process Learning Or Memory Cognition Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Proliferation Cell Migration Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Cell Migration Extracellular Matrix Organization Associative Learning Extracellular Structure Organization Locomotion Cell Motility Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Tissue Development Cell-substrate Adhesion Positive Regulation Of Endocytosis Leukocyte Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Single-organism Behavior Mesodermal Cell Differentiation Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling	Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell Adhesion Mediated By Integrin Reproduction Negative Regulation Of Rho Protein Signal Transduction Cell Adhesion Single Organism Reproductive Process Cell-matrix Adhesion Regulation Of Body Fluid Levels Reproductive Process Wound Healing Regulation Of Cell-substrate Adhesion Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Junction Assembly Regulation Of Cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Cell-substrate Adhesion Mesodermal Cell Differentiation Leukocyte Migration Response To Wounding Response To Gonadotropin Sexual Reproduction Viral Entry Into Host Cell Regulation Of Establishment Of Protein Localization To Plasma Membrane Entry Into Host Cell Multicellular Organism Reproduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Signal Transduction Maternal Process Involved In Female Pregnancy Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Signaling Mesoderm Formation Mesoderm Morphogenesis Locomotion Interaction With Host Cell-cell Junction Assembly Viral Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Single Fertilization Formation Of Primary Germ Layer Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component
Tagcloud ?		accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted
Tagcloud (Difference) ?		accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted
Tagcloud (Intersection) ?