CD8B and ST3GAL4

Number of citations of the paper that reports this interaction (PMID 12459555)
19

Data Source:
HPRD (in vitro)

		CD8B	ST3GAL4
Gene Name		CD8b molecule	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Early Endosome Membrane T Cell Receptor Complex	Golgi Membrane Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response	Carbohydrate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Pathogenesis O-glycan Processing Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Cognition Sialylation
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Nef Mediated CD8 Down-regulation The role of Nef in HIV-1 replication and disease pathogenesis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) O-linked glycosylation N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome
Drugs
Diseases
GWAS		Progressive supranuclear palsy ( 21685912)	Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		3 interactors: CD3D CD8A ST3GAL4	2 interactors: ARHGDIA CD8B
Entrez ID		926	6484
HPRD ID		01725	00084
Ensembl ID		ENSG00000172116	ENSG00000110080
Uniprot IDs		P10966	Q11206 Q6IBE6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytotoxic T Cell Differentiation T Cell Differentiation Lymphocyte Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Positive Thymic T Cell Selection Leukocyte Activation Single Organismal Cell-cell Adhesion Hemopoiesis Cell Activation Immune System Development Thymic T Cell Selection Keratan Sulfate Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling Keratan Sulfate Metabolic Process Regulation Of Immune Response T Cell Mediated Immunity T Cell Selection Regulation Of Calcium-mediated Signaling O-glycan Processing Sialylation Dolichol-linked Oligosaccharide Biosynthetic Process Cell Adhesion T Cell Differentiation In Thymus Regulation Of Immune System Process T Cell Costimulation Protein O-linked Glycosylation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
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