ST3GAL4 and CD8B

Number of citations of the paper that reports this interaction (PMID 12459555)
19

Data Source:
HPRD (in vitro)

		ST3GAL4	CD8B
Gene Name		ST3 beta-galactoside alpha-2,3-sialyltransferase 4	CD8b molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Early Endosome Membrane T Cell Receptor Complex
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity	Protein Binding Coreceptor Activity MHC Class I Protein Binding
	Biological Process	Carbohydrate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Pathogenesis O-glycan Processing Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Cognition Sialylation	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response
Pathways		Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) O-linked glycosylation N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Nef Mediated CD8 Down-regulation The role of Nef in HIV-1 replication and disease pathogenesis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Liver enzyme levels (alkaline phosphatase) ( 22001757)	Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		2 interactors: ARHGDIA CD8B	3 interactors: CD3D CD8A ST3GAL4
Entrez ID		6484	926
HPRD ID		00084	01725
Ensembl ID		ENSG00000110080	ENSG00000172116
Uniprot IDs		Q11206 Q6IBE6	P10966
PDB IDs
Enriched GO Terms of Interacting Partners?			Cytotoxic T Cell Differentiation T Cell Differentiation Lymphocyte Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Positive Thymic T Cell Selection Leukocyte Activation Single Organismal Cell-cell Adhesion Hemopoiesis Cell Activation Immune System Development Thymic T Cell Selection Keratan Sulfate Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling Keratan Sulfate Metabolic Process Regulation Of Immune Response T Cell Mediated Immunity T Cell Selection Regulation Of Calcium-mediated Signaling O-glycan Processing Sialylation Dolichol-linked Oligosaccharide Biosynthetic Process Cell Adhesion T Cell Differentiation In Thymus Regulation Of Immune System Process T Cell Costimulation Protein O-linked Glycosylation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
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