SLC6A5 and STX1A

Number of citations of the paper that reports this interaction (PMID 15276154)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SLC6A5	STX1A
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 5	syntaxin 1A (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Neurotransmitter:sodium Symporter Activity Glycine:sodium Symporter Activity	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Transport Neurotransmitter Transport Synaptic Transmission Glycine Import Transmembrane Transport Synaptic Transmission, Glycinergic	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Na+/Cl- dependent neurotransmitter transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: LNX1 SDCBP STX1A	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		9152	6804
HPRD ID		08378	01721
Ensembl ID			ENSG00000106089
Uniprot IDs		Q4VAM5 Q4VAM6 Q9Y345	A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Exocytosis Regulation Of Exocytosis Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Secretion Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Fusion To Presynaptic Membrane Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Synaptic Transmission Response To Gravity Positive Regulation Of Neurotransmitter Secretion Regulation Of Secretion Positive Regulation Of Transport Glutamate Secretion Positive Regulation Of Organelle Assembly Membrane Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Cell-cell Signaling Intracellular Protein Transport Substrate-dependent Cell Migration Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Regulation Of Cellular Localization Calcium Ion-dependent Exocytosis Vesicle Fusion Synaptic Vesicle Exocytosis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Acid Secretion Vesicle Docking Involved In Exocytosis Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Organelle Fusion Regulation Of Postsynaptic Membrane Potential Protein Transport Vesicle Docking Dicarboxylic Acid Transport Establishment Of Protein Localization Membrane Docking Intracellular Transport Ephrin Receptor Signaling Pathway Neurotransmitter Secretion Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Membrane Depolarization	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		apnea calnexin cardiorespiratory coat constitutes dampening exaggerated exit glycine glycinergic glyt2 heterologous hyperekplexia impeded misfolding neurotransmission presynaptic provoked provoking releasable retains s512r sec24d startle sudden tactile transmitter transporter trivial	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		apnea calnexin cardiorespiratory coat constitutes dampening exaggerated exit glycine glycinergic glyt2 heterologous hyperekplexia impeded misfolding neurotransmission presynaptic provoked provoking releasable retains s512r sec24d startle sudden tactile transmitter transporter trivial	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?