AIP and ARNT

Number of citations of the paper that reports this interaction (PMID 9111057)
50

Data Source:
HPRD (in vitro, in vivo)

		AIP	ARNT
Gene Name		aryl hydrocarbon receptor interacting protein	aryl hydrocarbon receptor nuclear translocator
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Protein Binding Transcription Factor Binding GAF Domain Binding Unfolded Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Aryl Hydrocarbon Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Enhancer Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Signal Transduction Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Nucleic Acid-templated Transcription	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Positive Regulation Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways			Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS			Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552) Urate levels ( 23263486)
Protein-Protein Interactions		16 interactors: AHR ARNT CLEC7A CSNK2A1 EGFR GNA13 GNAQ HSP90AA1 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20	37 interactors: ADH5 AHR AHRR AIP ARNT2 BRCA1 CSNK2A1 DIABLO EP300 EPAS1 ESR1 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HIF1A IRAK4 LSM8 MTA3 NCOA1 NCOA2 NCOA7 NCOR2 NPAS4 PML PTGES3 SENP6 SIM1 SIM2 SMAD9 SP1 SRC STRBP TNFAIP1 TRIP11 UBE2I
Entrez ID		9049	405
HPRD ID		10408	00524
Ensembl ID		ENSG00000110711	ENSG00000143437
Uniprot IDs		O00170	A8K6P0 B0AZM1 F8WAP6 P27540
PDB IDs		2LKN 4AIF 4APO	1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Signal Transduction Response To Stress Signaling Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Metabolic Process Cellular Response To Stimulus Positive Regulation Of Phospholipase Activity Response To Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Protein Refolding Response To External Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Catenin Import Into Nucleus Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Glycolytic Process Regulation Of Cellular Response To Heat Circadian Rhythm Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Gene Expression Negative Regulation Of Cell Death Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Activation Of Phospholipase C Activity Response To Abiotic Stimulus Regulation Of Innate Immune Response Cellular Response To Drug Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Alkanesulfonate Metabolic Process Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Transmembrane Transport Toll-like Receptor 9 Signaling Pathway	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Tube Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Signaling Intracellular Receptor Signaling Pathway Embryonic Placenta Development Cell Communication Reproductive Structure Development Response To Stimulus Negative Regulation Of Biosynthetic Process Reproductive System Development Regulation Of Cellular Process Embryo Development Organ Development Single Organism Reproductive Process Multicellular Organismal Development
Tagcloud ?		aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp	belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Difference) ?		aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp	belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Intersection) ?