AIP and PTGES3

Number of citations of the paper that reports this interaction (PMID 11259606)
23

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		AIP	PTGES3
Gene Name		aryl hydrocarbon receptor interacting protein	prostaglandin E synthase 3 (cytosolic)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Protein Binding Transcription Factor Binding GAF Domain Binding Unfolded Protein Binding	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Signal Transduction Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Nucleic Acid-templated Transcription	Telomere Maintenance Prostaglandin Biosynthetic Process RNA-dependent DNA Replication Signal Transduction Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Cellular Response To Heat Small Molecule Metabolic Process Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat
Pathways			Arachidonic acid metabolism HSF1 activation HSF1-dependent transactivation Metabolism of lipids and lipoproteins Attenuation phase Cellular response to heat stress Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		16 interactors: AHR ARNT CLEC7A CSNK2A1 EGFR GNA13 GNAQ HSP90AA1 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20	25 interactors: AHR AIP ARNT CASP3 CASP7 CAV3 CD2AP COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A NR3C1 NR3C2 STIP1 SURF1 TERT THRA
Entrez ID		9049	10728
HPRD ID		10408	06138
Ensembl ID		ENSG00000110711	ENSG00000110958
Uniprot IDs		O00170	Q15185
PDB IDs		2LKN 4AIF 4APO	1EJF 1LG0
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Signal Transduction Response To Stress Signaling Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Metabolic Process Cellular Response To Stimulus Positive Regulation Of Phospholipase Activity Response To Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Protein Refolding Response To External Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Catenin Import Into Nucleus Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Glycolytic Process Regulation Of Cellular Response To Heat Circadian Rhythm Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Gene Expression Negative Regulation Of Cell Death Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Activation Of Phospholipase C Activity Response To Abiotic Stimulus Regulation Of Innate Immune Response Cellular Response To Drug Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Alkanesulfonate Metabolic Process Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Transmembrane Transport Toll-like Receptor 9 Signaling Pathway	Regulation Of Cellular Response To Heat Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Regulation Of Apoptotic Process Regulation Of Cell Proliferation Protein Refolding Response To Temperature Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Death Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Heat Regulation Of Nitric-oxide Synthase Activity Response To Unfolded Protein Hormone-mediated Signaling Pathway Regulation Of Protein Complex Assembly Transcription From RNA Polymerase II Promoter Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Regulation Of Immune System Process Signal Transduction Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Negative Regulation Of Inclusion Body Assembly Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Regulation Of Oxidoreductase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C DNA-templated Transcription, Initiation Response To Abiotic Stimulus Positive Regulation Of Microtubule Polymerization Signaling Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Metabolic Process Protein Folding Nucleobase-containing Compound Metabolic Process
Tagcloud ?		aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp	12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage
Tagcloud (Difference) ?		aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp	12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage
Tagcloud (Intersection) ?