AIP and GNAQ

Number of citations of the paper that reports this interaction (PMID 19390533)
5

Data Source:
BioGRID (pull down)

		AIP	GNAQ
Gene Name		aryl hydrocarbon receptor interacting protein	guanine nucleotide binding protein (G protein), q polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Protein Binding Transcription Factor Binding GAF Domain Binding Unfolded Protein Binding	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Signal Transduction Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Nucleic Acid-templated Transcription	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways			G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: AHR ARNT CLEC7A CSNK2A1 EGFR GNA13 GNAQ HSP90AA1 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		9049	2776
HPRD ID		10408	02998
Ensembl ID		ENSG00000110711
Uniprot IDs		O00170	P50148
PDB IDs		2LKN 4AIF 4APO
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Signal Transduction Response To Stress Signaling Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Metabolic Process Cellular Response To Stimulus Positive Regulation Of Phospholipase Activity Response To Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Protein Refolding Response To External Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Catenin Import Into Nucleus Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Glycolytic Process Regulation Of Cellular Response To Heat Circadian Rhythm Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Gene Expression Negative Regulation Of Cell Death Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Activation Of Phospholipase C Activity Response To Abiotic Stimulus Regulation Of Innate Immune Response Cellular Response To Drug Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Alkanesulfonate Metabolic Process Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Transmembrane Transport Toll-like Receptor 9 Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		aminolaevulinate aspect autosomal coproporphyria counterparts cutanea decarboxylase dehydratase develops elucidating hepatoerythropoietic hereditary heteroallelic homo inherited intermittent mutational overt pct porphyria porphyrias puberty rarely recessive tarda uncommon uroporphyrinogen variegate vp	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?