EIF2B3 and EIF2S1

Number of citations of the paper that reports this interaction (PMID 16288713)
3

Data Source:
HPRD (in vitro)

		EIF2B3	EIF2S1
Gene Name		eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Nucleotidyltransferase Activity	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding
	Biological Process	Translation Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EIF2S1 EIF2S2 GOLM1 NDUFB8 STC2	19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT
Entrez ID		8891	1965
HPRD ID		09379	04881
Ensembl ID		ENSG00000070785	ENSG00000134001
Uniprot IDs		Q9HA31 Q9NR50	P05198 Q53XC0
PDB IDs			1KL9 1Q8K
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Male Germ Cell Proliferation Translational Initiation Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress	Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression
Tagcloud ?		1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm	atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin
Tagcloud (Difference) ?		1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm	atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin
Tagcloud (Intersection) ?