IL1RL2 and IL18

Number of citations of the paper that reports this interaction (PMID 9325300)
62

Data Source:
HPRD (in vivo, in vitro)

		IL1RL2	IL18
Gene Name		interleukin 1 receptor-like 2	interleukin 18
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity	Cytokine Activity Protein Binding
	Biological Process	Inflammatory Response Cellular Defense Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway	MAPK Cascade Angiogenesis Inflammatory Response Immune Response Cell-cell Signaling Positive Regulation Of Gene Expression Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Chemokine Biosynthetic Process T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-2 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Interleukin-13 Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of NK T Cell Proliferation Cellular Response To Organic Cyclic Compound
Pathways			Signaling by Interleukins Interleukin-1 processing Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Inflammatory bowel disease ( 23128233)	Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		1 interactors: IL18	8 interactors: CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		8808	3606
HPRD ID		05150	02976
Ensembl ID		ENSG00000115598	ENSG00000150782
Uniprot IDs		A4FU63 Q9HB29	Q14116
PDB IDs			1J0S 2VXT 3F62 4EEE 4EKX 4HJJ
Enriched GO Terms of Interacting Partners?		Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of NK T Cell Proliferation Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Interleukin-2 Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Cytokine Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Cytokine Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cytokine Production Regulation Of T Cell Proliferation Regulation Of Muscle Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Intracellular Protein Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Import Into Nucleus	Execution Phase Of Apoptosis Immune System Process Immune Response T-helper 1 Type Immune Response Response To Cytokine Regulation Of Inflammatory Response Cellular Response To Organic Substance Positive Regulation Of Cytokine Production Interleukin-18-mediated Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Organic Substance Regulation Of Cytokine Production Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Positive Regulation Of Endopeptidase Activity Regulation Of Cell Adhesion Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Adhesion Regulation Of Cysteine-type Endopeptidase Activity Glial Cell Apoptotic Process Response To Stress Regulation Of Apoptotic DNA Fragmentation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Apoptotic Process Adaptive Immune Response Programmed Cell Death Negative Regulation Of Keratinocyte Proliferation Cell Death Regulation Of T Cell Activation Death Regulation Of Cellular Process Positive Regulation Of Proteolysis Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Tagcloud ?		36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rap il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding	advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Difference) ?		36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rap il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding	advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Intersection) ?