IL18 and IL18R1

Number of citations of the paper that reports this interaction (PMID 9325300)
62

Data Source:
HPRD (in vivo, in vitro)

		IL18	IL18R1
Gene Name		interleukin 18	interleukin 18 receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Protein Binding	Receptor Activity Interleukin-1 Receptor Activity Protein Binding Interleukin-18 Receptor Activity
	Biological Process	MAPK Cascade Angiogenesis Inflammatory Response Immune Response Cell-cell Signaling Positive Regulation Of Gene Expression Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Chemokine Biosynthetic Process T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-2 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Interleukin-13 Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of NK T Cell Proliferation Cellular Response To Organic Cyclic Compound	Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus T-helper 1 Cell Differentiation
Pathways		Signaling by Interleukins Interleukin-1 processing Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Asthma ( 23028483 20860503 22561531) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	4 interactors: CD48 IL18 IL1RAP IL37
Entrez ID		3606	8809
HPRD ID		02976	05138
Ensembl ID		ENSG00000150782	ENSG00000115604
Uniprot IDs		Q14116	B7ZKV7 Q13478
PDB IDs		1J0S 2VXT 3F62 4EEE 4EKX 4HJJ
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Immune System Process Immune Response T-helper 1 Type Immune Response Response To Cytokine Regulation Of Inflammatory Response Cellular Response To Organic Substance Positive Regulation Of Cytokine Production Interleukin-18-mediated Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Organic Substance Regulation Of Cytokine Production Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Positive Regulation Of Endopeptidase Activity Regulation Of Cell Adhesion Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Adhesion Regulation Of Cysteine-type Endopeptidase Activity Glial Cell Apoptotic Process Response To Stress Regulation Of Apoptotic DNA Fragmentation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Apoptotic Process Adaptive Immune Response Programmed Cell Death Negative Regulation Of Keratinocyte Proliferation Cell Death Regulation Of T Cell Activation Death Regulation Of Cellular Process Positive Regulation Of Proteolysis Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C	Interleukin-2 Biosynthetic Process Interleukin-2 Production Cytokine Biosynthetic Process Cytokine Metabolic Process Defense Response Inflammatory Response Immune System Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Cytokine Production Interferon-gamma Biosynthetic Process Response To Stress Positive Regulation Of NK T Cell Proliferation Immune Response Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Activation Response To Organic Substance T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Response To Cytokine Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Response To Stimulus Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda	affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda	affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc
Tagcloud (Intersection) ?