SUCLA2 and ALAS2

Number of citations of the paper that reports this interaction (PMID 10727444)
6

Data Source:
HPRD (in vivo)

		SUCLA2	ALAS2
Gene Name		succinate-CoA ligase, ADP-forming, beta subunit	5-aminolevulinate synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Succinate-CoA Ligase (ADP-forming) Activity Protein Binding ATP Binding Metal Ion Binding	5-aminolevulinate Synthase Activity Protein Binding Glycine Binding Pyridoxal Phosphate Binding Coenzyme Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Pathway Cellular Metabolic Process Small Molecule Metabolic Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Cellular Iron Ion Homeostasis Erythrocyte Differentiation Oxygen Homeostasis Hemoglobin Biosynthetic Process Small Molecule Metabolic Process
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Heme biosynthesis Metabolism of porphyrins
Drugs			Glycine
Diseases
GWAS		Aging (time to event) ( 21782286) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		5 interactors: AGTRAP ALAS2 ARL6IP1 CMTM5 FAM9B	4 interactors: BANP GRB2 RABGGTB SUCLA2
Entrez ID		8803	212
HPRD ID		06798	02356
Ensembl ID		ENSG00000136143	ENSG00000158578
Uniprot IDs		E5KS60 F5GXC8 F5H5G8 Q9P2R7 Q9Y4T0	P22557
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Hypoxia Hemoglobin Biosynthetic Process Angiotensin-activated Signaling Pathway Oxygen Homeostasis Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process Hemoglobin Metabolic Process Negative Regulation Of Myoblast Differentiation Heme Biosynthetic Process	Succinyl-CoA Pathway Uroporphyrinogen III Biosynthetic Process
Tagcloud ?		970g acidemia athetoid carnitine caudate cnki consanguineous cousins dicarboxylic encephalomyopathic faroe hgmd hyperintensities hyperkinesia hypotonia kyphosis methylmalonic mma neurology ophthalmoplegia psychomotor ptosis putamen retardation scoliosis thoracocyllosis thrive uria wanfang	abcb7 advance asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		970g acidemia athetoid carnitine caudate cnki consanguineous cousins dicarboxylic encephalomyopathic faroe hgmd hyperintensities hyperkinesia hypotonia kyphosis methylmalonic mma neurology ophthalmoplegia psychomotor ptosis putamen retardation scoliosis thoracocyllosis thrive uria wanfang	abcb7 advance asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?