ALAS2 and SUCLA2

Number of citations of the paper that reports this interaction (PMID 10727444)
6

Data Source:
HPRD (in vivo)

		ALAS2	SUCLA2
Gene Name		5-aminolevulinate synthase 2	succinate-CoA ligase, ADP-forming, beta subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Glycine Binding Pyridoxal Phosphate Binding Coenzyme Binding	Succinate-CoA Ligase (ADP-forming) Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Cellular Iron Ion Homeostasis Erythrocyte Differentiation Oxygen Homeostasis Hemoglobin Biosynthetic Process Small Molecule Metabolic Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Succinyl-CoA Pathway Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Heme biosynthesis Metabolism of porphyrins	Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs		Glycine
Diseases
GWAS			Aging (time to event) ( 21782286) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		4 interactors: BANP GRB2 RABGGTB SUCLA2	5 interactors: AGTRAP ALAS2 ARL6IP1 CMTM5 FAM9B
Entrez ID		212	8803
HPRD ID		02356	06798
Ensembl ID		ENSG00000158578	ENSG00000136143
Uniprot IDs		P22557	E5KS60 F5GXC8 F5H5G8 Q9P2R7 Q9Y4T0
PDB IDs
Enriched GO Terms of Interacting Partners?		Succinyl-CoA Pathway Uroporphyrinogen III Biosynthetic Process	Response To Hypoxia Hemoglobin Biosynthetic Process Angiotensin-activated Signaling Pathway Oxygen Homeostasis Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process Hemoglobin Metabolic Process Negative Regulation Of Myoblast Differentiation Heme Biosynthetic Process
Tagcloud ?		abcb7 advance asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome	970g acidemia athetoid carnitine caudate cnki consanguineous cousins dicarboxylic encephalomyopathic faroe hgmd hyperintensities hyperkinesia hypotonia kyphosis methylmalonic mma neurology ophthalmoplegia psychomotor ptosis putamen retardation scoliosis thoracocyllosis thrive uria wanfang
Tagcloud (Difference) ?		abcb7 advance asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome	970g acidemia athetoid carnitine caudate cnki consanguineous cousins dicarboxylic encephalomyopathic faroe hgmd hyperintensities hyperkinesia hypotonia kyphosis methylmalonic mma neurology ophthalmoplegia psychomotor ptosis putamen retardation scoliosis thoracocyllosis thrive uria wanfang
Tagcloud (Intersection) ?