RFXANK and RFX5

Number of citations of the paper that reports this interaction (PMID 15964851)
5

Data Source:
HPRD (in vivo)

		RFXANK	RFX5
Gene Name		regulatory factor X-associated ankyrin-containing protein	regulatory factor X, 5 (influences HLA class II expression)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intercellular Bridge	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Histone Deacetylase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Ras Protein Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CIITA HDAC4 HDAC5 RAF1 RFX5 RFXAP	5 interactors: ANKRA2 CIITA HDAC2 RFXANK RFXAP
Entrez ID		8625	5993
HPRD ID		04435	03517
Ensembl ID		ENSG00000064490	ENSG00000143390
Uniprot IDs		O14593 Q24JQ1	B7Z848 P48382
PDB IDs		3UXG 3V30	2KW3 3V30
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Striated Muscle Cell Differentiation Histone H4 Deacetylation Osteoblast Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Deacetylation Negative Regulation Of Cellular Metabolic Process Histone H3-K9 Modification Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myotube Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Regulation Of Skeletal Muscle Tissue Development Protein Deacetylation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Defense Response Negative Regulation Of Ossification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Striated Muscle Cell Differentiation Death-inducing Signaling Complex Assembly B Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Osteoblast Differentiation Cell Activation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Striated Muscle Tissue Development Osteoblast Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Binding Regulation Of Muscle Cell Differentiation B Cell Activation Chromatin Remodeling Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Ossification Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Gene Expression, Epigenetic	Regulation Of Collagen Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Maintenance Of Chromatin Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Fungiform Papilla Formation Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Fungiform Papilla Morphogenesis Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Regulation Of Sarcomere Organization Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Positive Regulation Of Oligodendrocyte Differentiation Tongue Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Histone H3 Deacetylation Negative Regulation Of Organ Growth Tongue Development Positive Regulation Of Glial Cell Differentiation Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Regulation Of Oligodendrocyte Differentiation Regulation Of Cardiac Muscle Cell Proliferation RNA Biosynthetic Process Negative Regulation Of Striated Muscle Tissue Development Response To Cocaine
Tagcloud ?		ankra2 ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 sequester serving switch tumbler uncharacterized uncover	bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y
Tagcloud (Difference) ?		ankra2 ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue sequester serving switch tumbler uncharacterized uncover	bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y
Tagcloud (Intersection) ?		rfx5