RFX5 and RFXAP

Number of citations of the paper that reports this interaction (PMID 9118943)
42

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		RFX5	RFXAP
Gene Name		regulatory factor X, 5 (influences HLA class II expression)	regulatory factor X-associated protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ANKRA2 CIITA HDAC2 RFXANK RFXAP	4 interactors: EPS8 RFX5 RFXANK SMARCA4
Entrez ID		5993	5994
HPRD ID		03517	03515
Ensembl ID		ENSG00000143390	ENSG00000133111
Uniprot IDs		B7Z848 P48382	O00287
PDB IDs		2KW3 3V30	2KW3
Enriched GO Terms of Interacting Partners?		Regulation Of Collagen Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Maintenance Of Chromatin Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Fungiform Papilla Formation Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Fungiform Papilla Morphogenesis Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Regulation Of Sarcomere Organization Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Positive Regulation Of Oligodendrocyte Differentiation Tongue Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Histone H3 Deacetylation Negative Regulation Of Organ Growth Tongue Development Positive Regulation Of Glial Cell Differentiation Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Regulation Of Oligodendrocyte Differentiation Regulation Of Cardiac Muscle Cell Proliferation RNA Biosynthetic Process Negative Regulation Of Striated Muscle Tissue Development Response To Cocaine	Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Actin Polymerization-dependent Cell Motility Ras Protein Signal Transduction DNA Methylation On Cytosine Within A CG Sequence Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Exit From Mitosis Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Behavioral Response To Ethanol Positive Regulation By Host Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Negative Regulation Of Androgen Receptor Signaling Pathway Nucleosome Disassembly Blastocyst Hatching Rac Protein Signal Transduction Heart Trabecula Formation Lens Fiber Cell Development Vascular Smooth Muscle Cell Differentiation Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Glial Cell Fate Commitment RNA Biosynthetic Process Small GTPase Mediated Signal Transduction Definitive Hemopoiesis Heart Trabecula Morphogenesis Blastocyst Growth Interaction With Symbiont Chromatin Silencing Lens Fiber Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Binding Epidermis Morphogenesis Histone H3 Acetylation Positive Regulation Of Viral Transcription Actin Filament Capping Trabecula Morphogenesis Embryonic Hindlimb Morphogenesis Cell Fate Determination Skin Morphogenesis RNA Metabolic Process Neural Retina Development Smooth Muscle Cell Differentiation Negative Regulation Of Actin Filament Depolymerization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 x2 y	ankyrin assembles associate associates atf1 class coactivators coimmunoprecipitation compose cooperate enhanceosome leucine mhc module nlr nlrc5 nonderepressible nucleoprotein participates promoters repeats rfx5 rfxank tight transactivates w x1 x2
Tagcloud (Difference) ?		bind box boxes conserved contributions cus dictate dra effectors entire flanking functionally herpes heterodimer histocompatibility homodimer p36 plasmid proper rfx1 simplex spacing stabilized upstream vp16 y	ankyrin assembles associate associates atf1 class coactivators coimmunoprecipitation compose cooperate enhanceosome leucine mhc module nlr nlrc5 nonderepressible nucleoprotein participates promoters repeats rfxank tight transactivates w x1
Tagcloud (Intersection) ?		rfx5 x2