MKNK1 and MBP

Number of citations of the paper that reports this interaction (PMID 9155018)
137

Data Source:
HPRD (in vitro)

		MKNK1	MBP
Gene Name		MAP kinase interacting serine/threonine kinase 1	myelin basic protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Regulation Of Translational Initiation Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Response To Salt Stress Peptidyl-serine Phosphorylation Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid
Pathways		Signaling by FGFR in disease Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS			Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		25 interactors: APP ATXN3 CREBBP DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		8569	4155
HPRD ID		09468	01158
Ensembl ID		ENSG00000079277	ENSG00000197971
Uniprot IDs		A8K341 Q9BUB5	P02686
PDB IDs		2HW6 2Y9Q	1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Signaling Cellular Response To Stimulus Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Heat Enzyme Linked Receptor Protein Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stimulus Response To Cytokine Defense Response Regulation Of Cellular Response To Heat Viral Process Response To Abiotic Stimulus Innate Immune Response Signal Transduction Cellular Response To Cytokine Stimulus Toll-like Receptor Signaling Pathway Response To Stress Response To Heat Peptidyl-serine Phosphorylation Regulation Of Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Immune Response Positive Regulation Of Cellular Metabolic Process Innate Immune Response-activating Signal Transduction Cellular Protein Metabolic Process Regulation Of Translation Immune Response-regulating Signaling Pathway Immune System Process Activation Of Innate Immune Response Cell Cycle Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Death Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Gene Expression Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression	Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		4ebp1 90kda alphas1 alphas2 casein caseins cows dairy eif4e eif4g export igfbp3 igfbp5 lactating mtorc1 nonpregnant nucleocytoplasmic p70 p85 parenchymal patsearch rps6ka1 s6k ser209 ser2448 ser65 thr197202 thre389 thre412	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		4ebp1 90kda alphas1 alphas2 casein caseins cows dairy eif4e eif4g export igfbp3 igfbp5 lactating mtorc1 nonpregnant nucleocytoplasmic p70 p85 parenchymal patsearch rps6ka1 s6k ser209 ser2448 ser65 thr197202 thre389 thre412	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?