RHPN2 and KRT18

Number of citations of the paper that reports this interaction (PMID 12473120)
4

Data Source:
HPRD (in vitro, two hybrid)

		RHPN2	KRT18
Gene Name		rhophilin, Rho GTPase binding protein 2	keratin 18, type I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleolus Cytoplasm Microtubule Organizing Center Intermediate Filament Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function		Structural Molecule Activity Protein Binding Poly(A) RNA Binding Scaffold Protein Binding
	Biological Process	Signal Transduction	Cell Cycle Anatomical Structure Morphogenesis Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Colorectal cancer ( 19011631) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: KRT18 RARG RHOA RHOB SMURF1 TGFBR1	73 interactors: BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EGFR EP300 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 IKBKG KPNA2 KRT15 KRT5 KRT72 KRT8 LDOC1 MAPK14 NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE RAF1 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SUMO1 SVIL TCHP TNFRSF1B TRADD TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		85415	3875
HPRD ID		10192	01020
Ensembl ID		ENSG00000131941	ENSG00000111057
Uniprot IDs		Q8IUC4	P05783
PDB IDs		2VSV
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Chondrocyte Differentiation Cellular Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cartilage Development Anatomical Structure Morphogenesis Response To Organic Substance Anatomical Structure Development Rho Protein Signal Transduction Regulation Of Chondrocyte Differentiation Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Developmental Process Signaling Regulation Of Apoptotic Process Regulation Of Cartilage Development Cell Communication Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Death Skeletal System Development Golgi To Plasma Membrane CFTR Protein Transport Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cytokinesis Wound Healing Response To Growth Factor Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Positive Regulation Of Cell Death Tissue Development Cell Activation Cell Development Cytoplasmic Transport Response To Wounding Cellular Response To Stimulus Growth Plate Cartilage Chondrocyte Growth Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Intracellular Protein Transport Growth Plate Cartilage Chondrocyte Development Harderian Gland Development	Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway ERBB Signaling Pathway Cellular Component Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Membrane Organization Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Organization Innate Immune Response Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transport Anatomical Structure Development Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Signaling Mitotic Cell Cycle Phase Transition Cellular Response To Fibroblast Growth Factor Stimulus Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Developmental Process Defense Response Regulation Of Proteolysis Cellular Protein Localization Cellular Response To Stimulus
Tagcloud ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?