CASR and RNF19A

Number of citations of the paper that reports this interaction (PMID 16513638)
18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		CASR	RNF19A
Gene Name		calcium-sensing receptor	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Centrosome Integral Component Of Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G-protein Coupled Receptor Activity Protein Binding	Transcription Factor Binding Zinc Ion Binding Ligase Activity
	Biological Process	Ossification Detection Of Calcium Ion Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Chemosensory Behavior Metabolic Process Anatomical Structure Morphogenesis Calcium Ion Import	Microtubule Cytoskeleton Organization Protein Ubiquitination
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Cinacalcet
Diseases
GWAS		Calcium levels ( 20661308 20705733) Cardiac Troponin-T levels ( 23247143) Phosphorus levels ( 20558539)	Atrioventricular conduction ( 21041692)
Protein-Protein Interactions		7 interactors: FLNA PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP	16 interactors: C11orf58 CASR ILK MAP3K7 NUDT21 RPS6KA5 SNCAIP SOD1 SUFU TUBG1 TUBG2 UBE2E2 UBE2L3 UBE2L6 VCP ZAK
Entrez ID		846	25897
HPRD ID		03122	06176
Ensembl ID		ENSG00000036828	ENSG00000034677
Uniprot IDs		P41180	Q9NV58
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3-T6 Phosphorylation Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Glucose Transport Regulation Of Body Fluid Levels Wound Healing Mitotic Cell Cycle Process Cell Activation Response To Wounding Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Negative Regulation Of Insulin Receptor Signaling Pathway Histone Phosphorylation Nuclear Envelope Disassembly Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Cell Cycle Process Positive Regulation Of Phospholipase C Activity Negative Regulation Of Transport Regulation Of Insulin Receptor Signaling Pathway Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Mismatch Repair Positive Regulation Of Dense Core Granule Biogenesis Cell Cycle Regulation Of Glucose Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Protein Catabolic Process Nucleus Organization Positive Regulation Of Angiogenesis Regulation Of Mismatch Repair Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Response To Carbohydrate Cellular Response To Fibroblast Growth Factor Stimulus	Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process ISG15-protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAP Kinase Activity MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity JNK Cascade Cellular Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Catalytic Activity Signal Transduction By Phosphorylation Regulation Of Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Microtubule Nucleation Epithelial Tube Morphogenesis Protein K11-linked Ubiquitination Cellular Response To Organic Substance Activation Of MAPK Activity Response To Stress Microtubule Polymerization Tube Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Vasodilation Positive Regulation Of Kinase Activity Cytoplasmic Microtubule Organization Morphogenesis Of An Epithelium Microtubule Polymerization Or Depolymerization Regulation Of Cytokine Production Protein Complex Assembly Cell Cycle Process Myelination In Peripheral Nervous System Regulation Of Catalytic Activity Protein Ubiquitination Cellular Protein Modification Process Regulation Of Protein Phosphorylation Schwann Cell Development Epithelium Development Toll-like Receptor 5 Signaling Pathway Protein Modification By Small Protein Conjugation Toll-like Receptor 10 Signaling Pathway Regulation Of MAPK Cascade Cell Cycle Phase Transition Response To Organic Substance
Tagcloud ?		ascending balancing ca2 cations collecting concentrating divalent excretion furnish glands henle homeostatic hypercalcemia implicating insipidus integrating losses messenger mg2 mineral minimizes parathyroid phospholipases polyuria reabsorbtion reabsorption responds stone thyroidal
Tagcloud (Difference) ?		ascending balancing ca2 cations collecting concentrating divalent excretion furnish glands henle homeostatic hypercalcemia implicating insipidus integrating losses messenger mg2 mineral minimizes parathyroid phospholipases polyuria reabsorbtion reabsorption responds stone thyroidal
Tagcloud (Intersection) ?