CASR

Gene Name		calcium-sensing receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G-protein Coupled Receptor Activity Protein Binding
	Biological Process	Ossification Detection Of Calcium Ion Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Chemosensory Behavior Metabolic Process Anatomical Structure Morphogenesis Calcium Ion Import
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Cinacalcet
Diseases
GWAS		Calcium levels ( 20661308 20705733) Cardiac Troponin-T levels ( 23247143) Phosphorus levels ( 20558539)
Protein-protein Interactions		7 interactors: FLNA PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP
Entrez ID		846
HPRD ID		03122
Ensembl ID		ENSG00000036828
Uniprot IDs		P41180
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3-T6 Phosphorylation Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Glucose Transport Regulation Of Body Fluid Levels Wound Healing Mitotic Cell Cycle Process Cell Activation Response To Wounding Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Negative Regulation Of Insulin Receptor Signaling Pathway Histone Phosphorylation Nuclear Envelope Disassembly Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Cell Cycle Process Positive Regulation Of Phospholipase C Activity Negative Regulation Of Transport Regulation Of Insulin Receptor Signaling Pathway Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Mismatch Repair Positive Regulation Of Dense Core Granule Biogenesis Cell Cycle Regulation Of Glucose Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Protein Catabolic Process Nucleus Organization Positive Regulation Of Angiogenesis Regulation Of Mismatch Repair Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Response To Carbohydrate Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		ascending balancing ca2 cations collecting concentrating divalent excretion furnish glands henle homeostatic hypercalcemia implicating insipidus integrating losses messenger mg2 mineral minimizes parathyroid phospholipases polyuria reabsorbtion reabsorption responds stone thyroidal