PLD1 and PEA15

Number of citations of the paper that reports this interaction (PMID 10926929)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PLD1	PEA15
Gene Name		phospholipase D1, phosphatidylcholine-specific	phosphoprotein enriched in astrocytes 15
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Microtubule Associated Complex
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Defense Response To Gram-positive Bacterium	DNA Damage Checkpoint Transport Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	18 interactors: ABCD4 AK9 AKT1 CAMK2G CASP8 FADD HTRA2 L1CAM LUC7L2 MAPK1 MAPK3 PANK4 PDPK1 PLD1 PLD2 PRKCA RPS6KA3 TERF2IP
Entrez ID		5337	8682
HPRD ID		03855	04579
Ensembl ID		ENSG00000075651	ENSG00000162734
Uniprot IDs		Q13393 Q59EA4	B1AKZ3 B1AKZ4 B1AKZ5 Q15121
PDB IDs			4IZ5 4IZA
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Stimulus Regulation Of Body Fluid Levels Blood Coagulation Wound Healing Hemostasis Chemotaxis Cell Migration Platelet Activation Membrane Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Organization Cell Motility Response To Stimulus Response To Wounding Regulation Of Vesicle-mediated Transport Regulation Of Cellular Localization Actin Cytoskeleton Organization Actin Filament-based Process Vesicle-mediated Transport Cell Projection Organization Regulation Of Signaling Endocytosis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endocytosis Organelle Organization Cell Activation Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Cell Projection Assembly Anatomical Structure Morphogenesis Response To Stress Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Neuron Projection Morphogenesis Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Cell Death	Innate Immune Response Defense Response Positive Regulation Of Immune System Process Immune Response Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stress Toll-like Receptor 4 Signaling Pathway Response To Temperature Stimulus Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Epidermal Growth Factor Response To Growth Factor Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Programmed Cell Death Cell Activation Toll-like Receptor Signaling Pathway Response To Heat Response To Cytokine Cell Death Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Immune System Process Activation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Labyrinthine Layer Development Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Heat Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Cellular Response To Organic Substance Cellular Response To Mechanical Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Immune Response Platelet Activation
Tagcloud ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf	abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified
Tagcloud (Difference) ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf	abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified
Tagcloud (Intersection) ?