HIST2H2AA3 and BMI1

Number of citations of the paper that reports this interaction (PMID 21179169)
15

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		HIST2H2AA3	BMI1
Gene Name		histone cluster 2, H2aa3	BMI1 proto-oncogene, polycomb ring finger
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding
	Biological Process	Biological_process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development DNA Methylation Transcription, DNA-templated Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Histone Ubiquitination Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Apoptotic Signaling Pathway
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF2 RNF20 TBL1X UBE2H USP16 USP21	35 interactors: CBX6 CBX7 CBX8 CSNK2B E2F6 FOXS1 H2AFX HIST2H2AA3 HIST2H2AC HIST3H3 IMMT KAT5 KIAA1377 KMT2A LRIF1 MAPK14 NDEL1 PCGF3 PCGF6 PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D3 UBE2I USP11 USP7 VPS11 ZBTB16
Entrez ID		8337	648
HPRD ID		08851	01277
Ensembl ID			ENSG00000168283
Uniprot IDs		Q6FI13	P35226
PDB IDs			2H0D 3RPG
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Chromatin Modification Histone Modification Organelle Organization Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Histone Deubiquitination Histone Monoubiquitination Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Protein Monoubiquitination Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Catabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Histone Ubiquitination Cellular Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Gene Expression Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A Ubiquitination Protein Metabolic Process Negative Regulation Of Interleukin-2 Production Histone Monoubiquitination
Tagcloud ?			activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Difference) ?			activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Intersection) ?