LZTR1 and TRIM5

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		LZTR1	TRIM5
Gene Name		leucine-zipper-like transcription regulator 1	tripartite motif containing 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasmic MRNA Processing Body Cytoplasm Cytosol
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Signaling Pattern Recognition Receptor Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein Trimerization Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		50 interactors: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 IKBKG KDM2B L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	35 interactors: BTBD1 BTBD2 EWSR1 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PRKCG PSMC2 SUMO1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 USP15 USP2 USP21 USP39 USP5
Entrez ID		8216	85363
HPRD ID		08992	07004
Ensembl ID		ENSG00000099949	ENSG00000132256
Uniprot IDs		Q8N653	Q9C035
PDB IDs			2ECV 2YRG
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Chromatin Organization Viral Process Negative Regulation Of Cellular Metabolic Process Cellular Process Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Chromatin Modification DNA-templated Transcription, Elongation Chromatin Remodeling Positive Regulation Of Viral Transcription	Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Innate Immune Response Protein Deubiquitination Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Modification By Small Protein Removal Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Protein K48-linked Deubiquitination Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1
Tagcloud (Difference) ?			antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1
Tagcloud (Intersection) ?