LZTR1 and TFAP2B

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		LZTR1	TFAP2B
Gene Name		leucine-zipper-like transcription regulator 1	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Renal Water Homeostasis Glucose Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Lithium Ion Retina Layer Formation Magnesium Ion Homeostasis Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Urine Volume Aorta Morphogenesis Response To Drug Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Regulation Of Insulin Secretion Phosphate Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure Cellular Ammonia Homeostasis Cellular Creatinine Homeostasis Cellular Urea Homeostasis
Pathways
Drugs
Diseases
GWAS			Adiposity ( 19557161) Body mass index ( 23563607 20935630) Metabolic syndrome (bivariate traits) ( 21386085) Obesity ( 23563607) Obesity (extreme) ( 21935397) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		50 interactors: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 IKBKG KDM2B L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	11 interactors: CITED1 CITED2 CITED4 HIST1H2AC LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4
Entrez ID		8216	7021
HPRD ID		08992	03360
Ensembl ID		ENSG00000099949	ENSG00000008196
Uniprot IDs		Q8N653	Q92481
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Chromatin Organization Viral Process Negative Regulation Of Cellular Metabolic Process Cellular Process Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Chromatin Modification DNA-templated Transcription, Elongation Chromatin Remodeling Positive Regulation Of Viral Transcription	Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Organ Morphogenesis Response To Estrogen Positive Regulation Of Transcription, DNA-templated Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Response To Interleukin-11 Positive Regulation Of SUMO Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of Transcription, DNA-templated Kidney Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Cortex Formation Fibroblast Apoptotic Process Response To Steroid Hormone Axis Specification Regulation Of Gene Expression Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Mesonephros Development Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Interleukin-9 Transcription, DNA-templated Negative Regulation Of Gene Expression Nephron Development Negative Regulation Of Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia RNA Biosynthetic Process Kidney Epithelium Development Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Cellular Metabolic Process Determination Of Left/right Asymmetry In Lateral Mesoderm
Tagcloud ?			438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Difference) ?			438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Intersection) ?