LHX3 and LHX1

Number of citations of the paper that reports this interaction (PMID 9452425)
36

Data Source:
BioGRID (pull down)

		LHX3	LHX1
Gene Name		LIM homeobox 3	LIM homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Protein Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Zinc Ion Binding Sequence-specific DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Placenta Development Transcription From RNA Polymerase II Promoter Motor Neuron Axon Guidance Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development	Urogenital System Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Transcription From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Nervous System Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Horizontal Cell Localization Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis Pronephros Development Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Duct Development Nephric Duct Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Height ( 20189936) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		8 interactors: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM	5 interactors: FOXA2 ISL1 LHX3 OTX2 RLIM
Entrez ID		8022	3975
HPRD ID		02783	09067
Ensembl ID		ENSG00000107187	ENSG00000132130
Uniprot IDs		F1T0D5 F1T0D7 F1T0D9 Q9UBR4	P48742 Q58F18
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Spinal Cord Development Axis Specification Central Nervous System Development Pattern Specification Process Visceral Motor Neuron Differentiation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Anatomical Structure Morphogenesis Brain Development Generation Of Neurons Head Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Organ Development Axon Guidance Peripheral Nervous System Neuron Development Cerebellum Development Left/right Axis Specification Metencephalon Development Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Cell Differentiation Cerebellar Purkinje Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Embryo Development Cell Projection Organization Cerebellar Purkinje Cell Layer Morphogenesis Axonogenesis Nervous System Development Transcription, DNA-templated Hindbrain Development Axon Development Left/right Pattern Formation Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Organ Morphogenesis RNA Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Negative Regulation Of Biosynthetic Process Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Cerebellar Cortex Formation	Neuron Fate Commitment Cell Fate Specification Neuron Fate Specification Cell Fate Commitment Diencephalon Development Pattern Specification Process Positive Regulation Of Gastrulation Dorsal/ventral Pattern Formation Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Somite Rostral/caudal Axis Specification Spinal Cord Motor Neuron Cell Fate Specification Brain Development Head Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Central Nervous System Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Embryonic Development Regulation Of Gastrulation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Axon Guidance Cell Fate Determination Embryonic Axis Specification Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gastrulation With Mouth Forming Second Ventral Spinal Cord Development Forebrain Development Gene Expression Cell Differentiation In Spinal Cord Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Axis Specification Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Generation Of Neurons Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Axonogenesis Neurogenesis Somitogenesis Embryonic Pattern Specification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Smoothened Signaling Pathway
Tagcloud ?		balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lim lmo4 nli nucleates spinal v2 v2a v2b ventral	activin atp1b1 belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Difference) ?		balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lmo4 nli nucleates spinal v2 v2a v2b ventral	activin atp1b1 belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Intersection) ?		lim