LHX1 and OTX2

Number of citations of the paper that reports this interaction (PMID 10623575)
9

Data Source:
BioGRID (pull down)

		LHX1	OTX2
Gene Name		LIM homeobox 1	orthodenticle homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Protein Complex	Nucleus Cytoplasm Growth Cone Protein Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Eukaryotic Initiation Factor 4E Binding Protein Heterodimerization Activity
	Biological Process	Urogenital System Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Transcription From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Nervous System Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Horizontal Cell Localization Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis Pronephros Development Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Duct Development Nephric Duct Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Cell Fate Specification Protein Complex Assembly Axon Guidance Endoderm Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Metencephalon Development Forebrain Development Midbrain Development Somite Rostral/caudal Axis Specification Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Eye Photoreceptor Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Determination Diencephalon Morphogenesis Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: FOXA2 ISL1 LHX3 OTX2 RLIM	9 interactors: APP ATXN1 CDK4 DMBX1 FOXA2 LHX1 MITF TLE4 ZDHHC17
Entrez ID		3975	5015
HPRD ID		09067	07190
Ensembl ID		ENSG00000132130	ENSG00000165588
Uniprot IDs		P48742 Q58F18	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Fate Commitment Cell Fate Specification Neuron Fate Specification Cell Fate Commitment Diencephalon Development Pattern Specification Process Positive Regulation Of Gastrulation Dorsal/ventral Pattern Formation Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Somite Rostral/caudal Axis Specification Spinal Cord Motor Neuron Cell Fate Specification Brain Development Head Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Central Nervous System Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Embryonic Development Regulation Of Gastrulation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Axon Guidance Cell Fate Determination Embryonic Axis Specification Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gastrulation With Mouth Forming Second Ventral Spinal Cord Development Forebrain Development Gene Expression Cell Differentiation In Spinal Cord Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Axis Specification Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Generation Of Neurons Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Axonogenesis Neurogenesis Somitogenesis Embryonic Pattern Specification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Smoothened Signaling Pathway	Adult Locomotory Behavior Ectoderm Formation Adult Behavior Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Locomotory Behavior Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Somite Rostral/caudal Axis Specification Single-organism Behavior RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ectoderm Development Gene Expression Behavior Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Differentiation In Hindbrain Macromolecule Biosynthetic Process Positive Regulation Of Embryonic Development RNA Biosynthetic Process Signaling Regulation Of Gastrulation Cell Communication Positive Regulation Of Cellular Metabolic Process Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Growth System Development Regulation Of Cell Cycle G2/M Phase Transition Head Development Regulation Of Transcription, DNA-templated Embryonic Axis Specification Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second
Tagcloud ?		activin atp1b1 belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus	accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion specification sufficiently
Tagcloud (Difference) ?		activin atp1b1 belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves unfolded xenopus	accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion sufficiently
Tagcloud (Intersection) ?		specification