CENPU and NDUFS2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CENPU	NDUFS2
Gene Name		centromere protein U	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Microtubule Organizing Center Cytosol	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function		NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitotic Cell Cycle Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		17 interactors: EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	5 interactors: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		79682	4720
HPRD ID		14722	04285
Ensembl ID		ENSG00000151725	ENSG00000158864
Uniprot IDs		Q09GN2 Q71F23	B7Z792 O75306
PDB IDs
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis System Development Developmental Process Axon Guidance Nervous System Development Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Cell Differentiation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Locomotion Positive Regulation Of Cellular Protein Catabolic Process Neuron Projection Development Mitotic Cell Cycle Checkpoint Endomembrane System Organization Regulation Of Cellular Protein Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Cell Cycle Cell Part Morphogenesis Mitotic Nuclear Envelope Disassembly Regulation Of Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Movement Of Cell Or Subcellular Component Nuclear Envelope Disassembly Neuron Development Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Cell Cycle Process Cell Morphogenesis Regulation Of Cell Division Spliceosomal Complex Disassembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cytokinesis Neuron Differentiation Cell Projection Organization Nuclear Envelope Organization	Rhombomere 5 Formation Rhombomere 3 Formation Transition Metal Ion Homeostasis Rhombomere 3 Morphogenesis Synaptic Growth At Neuromuscular Junction Brain Segmentation Collateral Sprouting In Absence Of Injury Heme Oxidation Regulation Of Peptidyl-tyrosine Phosphorylation Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Rhombomere Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Locomotion Cognition Negative Regulation Of Alpha-beta T Cell Proliferation Heme Catabolic Process Neuron Remodeling Rhombomere Development Facial Nerve Structural Organization Regulation Of Cytokine Secretion Involved In Immune Response Axon Guidance Facial Nerve Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Response To Oxidative Stress Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of T Cell Migration Single-organism Behavior Metal Ion Homeostasis Cellular Copper Ion Homeostasis Response To External Stimulus Rhythmic Behavior Regulation Of T Cell Migration Parasympathetic Nervous System Development Regulation Of Cellular Ketone Metabolic Process Anatomical Structure Arrangement Copper Ion Homeostasis Suckling Behavior Axonogenesis Cellular Chemical Homeostasis Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?			accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Difference) ?			accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Intersection) ?