ZP3 and UBAP2L

Number of citations of the paper that reports this interaction (PMID 19945174)
4

Data Source:
BioGRID (two hybrid)

		ZP3	UBAP2L
Gene Name		zona pellucida glycoprotein 3 (sperm receptor)	ubiquitin associated protein 2-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm	Ada2/Gcn5/Ada3 Transcription Activator Complex
	Molecular Function	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Binding Of Sperm To Zona Pellucida
Pathways		Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	6 interactors: ATXN1 ITCH NEDD4 PLXNA2 PRRC2A ZP3
Entrez ID		7784	9898
HPRD ID		01690	06665
Ensembl ID		ENSG00000188372	ENSG00000143569
Uniprot IDs		P21754	F8W726 Q14157
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction	Protein K63-linked Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Cerebellar Granule Cell Precursor Tangential Migration Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Transmission Of Virus Positive Regulation Of Type IV Hypersensitivity Development Involved In Symbiotic Interaction Negative Regulation Of Cellular Metabolic Process Regulation Of T Cell Proliferation Hindbrain Tangential Cell Migration Egg Coat Formation Cellular Localization Protein Polyubiquitination Regulation Of Ovarian Follicle Development Intracellular Receptor Signaling Pathway Signaling Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Cell Communication Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Protein K29-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Regulation Of Protein Deubiquitination Positive Regulation Of Acrosome Reaction Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of T Cell Anergy Progesterone Receptor Signaling Pathway Adaptive Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Locomotion Immune Response Regulation Of T Cell Activation Positive Regulation Of Hypersensitivity Regulation Of Phosphorylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Tagcloud ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Difference) ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Intersection) ?