ZP3 and ENGASE

Number of citations of the paper that reports this interaction (PMID 8269854)
13

Data Source:
HPRD (in vitro)

		ZP3	ENGASE
Gene Name		zona pellucida glycoprotein 3 (sperm receptor)	endo-beta-N-acetylglucosaminidase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding	Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Metabolic Process
Pathways		Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	1 interactors: ZP3
Entrez ID		7784	64772
HPRD ID		01690	10978
Ensembl ID		ENSG00000188372
Uniprot IDs		P21754	Q8NFI3
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction	Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Regulation Of Ovarian Follicle Development Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Acrosome Reaction Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Manganese Ion Transmembrane Transport Regulation Of Acrosome Reaction Manganese Ion Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Female Gonad Development Positive Regulation Of Calcium Ion Import Positive Regulation Of Humoral Immune Response Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion Import Positive Regulation Of Interleukin-4 Production Positive Regulation Of Acute Inflammatory Response Protein Kinase C Signaling Regulation Of Interleukin-4 Production Blastocyst Formation Binding Of Sperm To Zona Pellucida Oocyte Development Oocyte Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Sperm-egg Recognition Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Exocytosis Cell-cell Recognition Regulation Of Acute Inflammatory Response Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Protein Kinase B Signaling Oogenesis Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Positive Regulation Of Leukocyte Migration Positive Regulation Of Calcium Ion Transport Positive Regulation Of Inflammatory Response Blastocyst Development Positive Regulation Of T Cell Mediated Immunity Female Gamete Generation Positive Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Migration
Tagcloud ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic	ablation catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded ngly1 phenotypic precise prone restored unconventional underscores
Tagcloud (Difference) ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic	ablation catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded ngly1 phenotypic precise prone restored unconventional underscores
Tagcloud (Intersection) ?