ZP3 and ACR

Number of citations of the paper that reports this interaction (PMID 11739644)
6

Data Source:
HPRD (in vitro)

		ZP3	ACR
Gene Name		zona pellucida glycoprotein 3 (sperm receptor)	acrosin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Golgi-associated Vesicle Acrosomal Matrix Protein Complex
	Molecular Function	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding	DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Drug Binding Zinc Ion Binding Fucose Binding
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Multicellular Organism Reproduction Response To Steroid Hormone
Pathways		Interaction With The Zona Pellucida Fertilization	Acrosome Reaction Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	3 interactors: SERPINA5 ZP2 ZP3
Entrez ID		7784	49
HPRD ID		01690	06342
Ensembl ID		ENSG00000188372	ENSG00000100312
Uniprot IDs		P21754	P10323
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction	Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Sexual Reproduction Multicellular Organism Reproduction Cell Recognition Reproduction Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Type IV Hypersensitivity Single Organism Reproductive Process Reproductive Process Egg Coat Formation Regulation Of Ovarian Follicle Development Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Acrosome Reaction Prevention Of Polyspermy Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Manganese Ion Transmembrane Transport Regulation Of Acrosome Reaction Manganese Ion Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Female Gonad Development Positive Regulation Of Calcium Ion Import Fusion Of Sperm To Egg Plasma Membrane Positive Regulation Of Humoral Immune Response Gamete Generation Positive Regulation Of Calcium Ion-dependent Exocytosis Plasma Membrane Fusion Egg Activation Regulation Of Calcium Ion Import Positive Regulation Of Interleukin-4 Production Multicellular Organismal Reproductive Process Positive Regulation Of Acute Inflammatory Response Protein Kinase C Signaling Regulation Of Interleukin-4 Production Intracellular Protein Transport Blastocyst Formation Oocyte Development Oocyte Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Lipid Biosynthetic Process
Tagcloud ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic	allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability
Tagcloud (Difference) ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic	allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability
Tagcloud (Intersection) ?