VHL and RPS15A

Number of citations of the paper that reports this interaction (PMID 22234250)
1

Data Source:
BioGRID (pull down)

		VHL	RPS15A
Gene Name		von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	ribosomal protein S15a
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane Intermediate Filament Cytoskeleton	Cytoplasm Cytosol Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation Response To Virus Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle
Pathways		Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		85 interactors: ACTB APP AR AURKA CAPN7 CAPZB CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CHEK2 CLU CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EPAS1 FKBP8 FLNA FN1 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HIST1H1C HIST1H2BL HIST4H4 HNRNPA2B1 HNRNPD HSPA5 HSPA8 JADE1 KIF2C KIF3A KLF4 LANCL1 MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PLD1 POLR2G PRDX1 PRKCD PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RNF139 RPL21 RPL5 RPS15A SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TCEB1 TCEB2 TRIM28 UBE2D1 USP20 USP33 UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	6 interactors: CALM1 CDC37 DDX39B ELF5 EWSR1 VHL
Entrez ID		7428	6210
HPRD ID		01905	04723
Ensembl ID			ENSG00000134419
Uniprot IDs		P40337	B2R4W8 P62244
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K	3J3A
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Cellular Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated RNA Metabolic Process Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Heterocycle Metabolic Process Positive Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Body Fluid Levels Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Wound Healing Regulation Of Signal Transduction Response To Stimulus	Protein Stabilization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Stability RNA Secondary Structure Unwinding Negative Regulation Of DNA Damage Checkpoint Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Metabolic Process Viral MRNA Export From Host Cell Nucleus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of DNA Damage Checkpoint Detection Of Calcium Ion Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Gene Expression Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Posttranscriptional Regulation Of Gene Expression Regulation Of Interferon-gamma-mediated Signaling Pathway Polysaccharide Catabolic Process Regulation Of Response To Interferon-gamma Positive Regulation Of Monooxygenase Activity Mammary Gland Epithelial Cell Differentiation Regulation Of Cell Cycle Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Ectoderm Development Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	4e 4f accounts brassica cdc33 cdc33ts4 cerevisiae clone drosophila eif grow multicopy name napus oogenesis phenomenon produces rescuing ribosomal saccharomyces shuttle stabilization suppressing temperature termed unaffected unrelated yeast
Tagcloud (Difference) ?		ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd	4e 4f accounts brassica cdc33 cdc33ts4 cerevisiae clone drosophila eif grow multicopy name napus oogenesis phenomenon produces rescuing ribosomal saccharomyces shuttle stabilization suppressing temperature termed unaffected unrelated yeast
Tagcloud (Intersection) ?