RPS15A and ELF5

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		RPS15A	ELF5
Gene Name		ribosomal protein S15a	E74-like factor 5 (ets domain transcription factor)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation Response To Virus Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Ectoderm Development Cell Proliferation Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Epithelial Cell Differentiation
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374)
Protein-Protein Interactions		6 interactors: CALM1 CDC37 DDX39B ELF5 EWSR1 VHL	8 interactors: ACTR2 FRZB NFE2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4
Entrez ID		6210	2001
HPRD ID		04723	05525
Ensembl ID		ENSG00000134419	ENSG00000135374
Uniprot IDs		B2R4W8 P62244	A6XAE6 A8K443 Q9UKW6
PDB IDs		3J3A	1WWX
Enriched GO Terms of Interacting Partners?		Protein Stabilization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Stability RNA Secondary Structure Unwinding Negative Regulation Of DNA Damage Checkpoint Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Metabolic Process Viral MRNA Export From Host Cell Nucleus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of DNA Damage Checkpoint Detection Of Calcium Ion Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Gene Expression Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Posttranscriptional Regulation Of Gene Expression Regulation Of Interferon-gamma-mediated Signaling Pathway Polysaccharide Catabolic Process Regulation Of Response To Interferon-gamma Positive Regulation Of Monooxygenase Activity Mammary Gland Epithelial Cell Differentiation Regulation Of Cell Cycle Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Ectoderm Development Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		4e 4f accounts brassica cdc33 cdc33ts4 cerevisiae clone drosophila eif grow multicopy name napus oogenesis phenomenon produces rescuing ribosomal saccharomyces shuttle stabilization suppressing temperature termed unaffected unrelated yeast	alveolar cited1 collectively conditional cre disruption encodes except foxa1 knockout lineage luminal master mature mechanistically mecs mmtv mutated profound rb1 represses rescued runx runx1 secretory subpopulation subpopulations tf trp53
Tagcloud (Difference) ?		4e 4f accounts brassica cdc33 cdc33ts4 cerevisiae clone drosophila eif grow multicopy name napus oogenesis phenomenon produces rescuing ribosomal saccharomyces shuttle stabilization suppressing temperature termed unaffected unrelated yeast	alveolar cited1 collectively conditional cre disruption encodes except foxa1 knockout lineage luminal master mature mechanistically mecs mmtv mutated profound rb1 represses rescued runx runx1 secretory subpopulation subpopulations tf trp53
Tagcloud (Intersection) ?