TRPC1 and TRPC5

Number of citations of the paper that reports this interaction (PMID 11301024)
139

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo)

		TRPC1	TRPC5
Gene Name		transient receptor potential cation channel, subfamily C, member 1	transient receptor potential cation channel, subfamily C, member 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Sarcomere Costamere Receptor Complex Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane Calcium Channel Complex
	Molecular Function	Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Ion Channel Binding Inositol 1,4,5 Trisphosphate Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Axon Guidance Ion Transmembrane Transport Saliva Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport	Calcium Ion Transport Nervous System Development Axon Guidance Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling
Drugs
Diseases
GWAS			Smoking behavior ( 19247474)
Protein-Protein Interactions		14 interactors: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5	7 interactors: ITPR3 MX1 SLC9A3R1 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		7220	7224
HPRD ID		11894	02273
Ensembl ID		ENSG00000144935	ENSG00000072315
Uniprot IDs		P48995	Q9UL62
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Metal Ion Transport Positive Regulation Of Calcium Ion Transport Response To Stimulus Response To Calcium Ion Regulation Of Cellular Localization Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cation Transport Ion Transport Cell Communication Response To External Stimulus Blood Coagulation Hemostasis Regulation Of Intracellular Transport Ion Transmembrane Transport Platelet Activation Positive Regulation Of Ion Transport Response To Inorganic Substance Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cation Transmembrane Transport Cellular Response To Stimulus Regulation Of Signaling Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Regulation Of Endothelial Cell Proliferation Wound Healing Regulation Of Transcription Factor Import Into Nucleus Anatomical Structure Morphogenesis Regulation Of Ion Transport Regulation Of Protein Transport Transmembrane Transport Response To Organic Substance Response To Stress Regulation Of Establishment Of Protein Localization Response To Metal Ion Response To Wounding Intracellular Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Inositol Phosphate-mediated Signaling Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Axon Guidance	Calcium Ion Transmembrane Transport Metal Ion Transport Calcium Ion Transport Acid Secretion Cell Projection Organization Cation Transport Regulation Of Microtubule Polymerization Or Depolymerization Cellular Ion Homeostasis Renal Phosphate Ion Absorption Cellular Chemical Homeostasis Ion Homeostasis Response To Calcium Ion Generation Of Neurons Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Secretion Monocarboxylic Acid Transport Neurogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Homeostasis Ion Transport Regulation Of Microtubule-based Process Gamma-aminobutyric Acid Secretion Cytosolic Calcium Ion Homeostasis Neuron Projection Development Renal Sodium Ion Transport Positive Regulation Of Microtubule Depolymerization Chemical Homeostasis Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Sensory Perception Of Sweet Taste Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Cation Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Rac Protein Signal Transduction Sensory Perception Of Umami Taste Neuron Development Nervous System Development Phospholipase C-activating Dopamine Receptor Signaling Pathway Gamma-aminobutyric Acid Transport Saliva Secretion Bile Acid Secretion Microtubule Depolymerization Cellular Calcium Ion Homeostasis Neuron Differentiation Carboxylic Acid Transport Calcium Ion Homeostasis Organic Acid Transport Oligopeptide Transport Negative Regulation Of Sodium Ion Transport
Tagcloud ?		ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl	allosteric ankyrin arises belongs branched channels detectors enthalpy evolved gating kcal macroscopic melastatin polymodal specialized subfamilies tetramers thermal trpa trpa1 trpm trpm8 trpv trpv1 trpv3 vanilloid voltage
Tagcloud (Difference) ?		ca2 cation cdna converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl	allosteric ankyrin arises belongs branched detectors enthalpy evolved gating kcal macroscopic melastatin polymodal specialized subfamilies tetramers thermal trpa trpa1 trpm trpm8 trpv trpv1 trpv3 vanilloid voltage
Tagcloud (Intersection) ?		channels