TRPC1 and TRPC4

Number of citations of the paper that reports this interaction (PMID 12032305)
131

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo)

		TRPC1	TRPC4
Gene Name		transient receptor potential cation channel, subfamily C, member 1	transient receptor potential cation channel, subfamily C, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Sarcomere Costamere Receptor Complex Membrane Raft	Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Calcium Channel Complex
	Molecular Function	Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Ion Channel Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Axon Guidance Ion Transmembrane Transport Saliva Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport	Calcium Ion Transport Axon Guidance Gamma-aminobutyric Acid Secretion Ion Transmembrane Transport Oligodendrocyte Differentiation Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5	9 interactors: ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID		7220	7223
HPRD ID		11894	09154
Ensembl ID		ENSG00000144935	ENSG00000133107
Uniprot IDs		P48995	Q3KR50 Q9UBN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Metal Ion Transport Positive Regulation Of Calcium Ion Transport Response To Stimulus Response To Calcium Ion Regulation Of Cellular Localization Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cation Transport Ion Transport Cell Communication Response To External Stimulus Blood Coagulation Hemostasis Regulation Of Intracellular Transport Ion Transmembrane Transport Platelet Activation Positive Regulation Of Ion Transport Response To Inorganic Substance Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cation Transmembrane Transport Cellular Response To Stimulus Regulation Of Signaling Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Regulation Of Endothelial Cell Proliferation Wound Healing Regulation Of Transcription Factor Import Into Nucleus Anatomical Structure Morphogenesis Regulation Of Ion Transport Regulation Of Protein Transport Transmembrane Transport Response To Organic Substance Response To Stress Regulation Of Establishment Of Protein Localization Response To Metal Ion Response To Wounding Intracellular Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Inositol Phosphate-mediated Signaling Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Axon Guidance	Calcium Ion Transmembrane Transport Inositol Phosphate-mediated Signaling Calcium Ion Transport Metal Ion Transport Cellular Chemical Homeostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Cation Transport Cellular Homeostasis Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemical Homeostasis Cation Transmembrane Transport Ion Transport Cellular Ion Homeostasis Energy Reserve Metabolic Process Immune Response-regulating Signaling Pathway Second-messenger-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Immune Response Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Secretion Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Homeostatic Process Fc-epsilon Receptor Signaling Pathway Response To Stimulus Phagocytosis Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Difference) ?		ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Intersection) ?		trpc1