TNR and NCK2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TNR	NCK2
Gene Name		tenascin R	NCK adaptor protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Nucleus Nucleoplasm Cytoplasm Cell Surface Membrane Raft Perineuronal Net	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane
	Molecular Function		SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Axon Guidance Associative Learning Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Locomotory Exploration Behavior Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation	Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		ECM proteoglycans	Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Tonometry ( 17903302)	Addiction ( 23533358)
Protein-Protein Interactions		15 interactors: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC POLR3C PSMA1 PTPRZ1 SIGLEC1 VCAN WDYHV1	80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B
Entrez ID		7143	8440
HPRD ID		03589	05378
Ensembl ID		ENSG00000116147	ENSG00000071051
Uniprot IDs		A1L306 Q92752	E7ERP6 O43639
PDB IDs			1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Dermatan Sulfate Biosynthetic Process Cell Adhesion Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Glycosaminoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Proteoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Pathogenesis Chondroitin Sulfate Metabolic Process Axonogenesis Nervous System Development Central Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Glycoprotein Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Glycoprotein Metabolic Process Neuron Development Neurogenesis Cell Morphogenesis Skeletal System Development Cell Development Neuron Differentiation Chemotaxis Cell Projection Organization Locomotion System Development Movement Of Cell Or Subcellular Component Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Multicellular Organismal Development Extracellular Matrix Disassembly Anatomical Structure Development Catabolic Process Carbohydrate Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development
Tagcloud ?		1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Difference) ?		1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Intersection) ?