TNR and NCAN

Number of citations of the paper that reports this interaction (PMID 9507007)
12

Data Source:
BioGRID (pull down)

		TNR	NCAN
Gene Name		tenascin R	neurocan
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Nucleus Nucleoplasm Cytoplasm Cell Surface Membrane Raft Perineuronal Net	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Lysosomal Lumen
	Molecular Function		Extracellular Matrix Structural Constituent Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Axon Guidance Associative Learning Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Locomotory Exploration Behavior Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Axon Guidance Central Nervous System Development Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process Regulation Of Synapse Structural Plasticity
Pathways		ECM proteoglycans	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism L1CAM interactions Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Tonometry ( 17903302)	Bipolar disorder ( 21353194) Cholesterol, total ( 19060911) LDL cholesterol ( 18193043 19060906 19060911) Triglycerides ( 18193043 19060906 19060911)
Protein-Protein Interactions		15 interactors: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC POLR3C PSMA1 PTPRZ1 SIGLEC1 VCAN WDYHV1	7 interactors: CNTN2 HMGB1 L1CAM NCAM1 PTN TNC TNR
Entrez ID		7143	1463
HPRD ID		03589	02897
Ensembl ID		ENSG00000116147	ENSG00000130287
Uniprot IDs		A1L306 Q92752	O14594 Q4LE67
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Dermatan Sulfate Biosynthetic Process Cell Adhesion Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Glycosaminoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Proteoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Pathogenesis Chondroitin Sulfate Metabolic Process Axonogenesis Nervous System Development Central Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Glycoprotein Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Glycoprotein Metabolic Process Neuron Development Neurogenesis Cell Morphogenesis Skeletal System Development Cell Development Neuron Differentiation Chemotaxis Cell Projection Organization Locomotion System Development Movement Of Cell Or Subcellular Component Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Multicellular Organismal Development Extracellular Matrix Disassembly Anatomical Structure Development Catabolic Process Carbohydrate Metabolic Process	Neuron Projection Development Neuron Development Neuron Differentiation Nervous System Development Cell Projection Organization Axon Development Chemotaxis Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance System Development Cell Adhesion Learning Locomotion Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Multicellular Organismal Development Anatomical Structure Development Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Developmental Process Learning Or Memory Cell Migration Cell Projection Morphogenesis Cell Differentiation Cell Part Morphogenesis Cognition Cell Motility Cell Morphogenesis Anatomical Structure Morphogenesis Single-organism Behavior Negative Regulation Of Axon Extension Involved In Regeneration Establishment Of Protein Localization To Juxtaparanode Region Of Axon Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of Apoptotic Cell Clearance Telencephalon Cell Migration Forebrain Cell Migration Behavior Organ Development Interferon-gamma-mediated Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To Stimulus Response To Ethanol
Tagcloud ?		1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride
Tagcloud (Difference) ?		1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride
Tagcloud (Intersection) ?