TNR and SIGLEC1

Number of citations of the paper that reports this interaction (PMID 10406848)
2

Data Source:
HPRD (in vitro)

		TNR	SIGLEC1
Gene Name		tenascin R	sialic acid binding Ig-like lectin 1, sialoadhesin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Nucleus Nucleoplasm Cytoplasm Cell Surface Membrane Raft Perineuronal Net	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function		Carbohydrate Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Axon Guidance Associative Learning Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Locomotory Exploration Behavior Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation	Endocytosis Inflammatory Response Cell-matrix Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		ECM proteoglycans
Drugs
Diseases
GWAS		Tonometry ( 17903302)
Protein-Protein Interactions		15 interactors: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC POLR3C PSMA1 PTPRZ1 SIGLEC1 VCAN WDYHV1	3 interactors: MUC1 SPN TNR
Entrez ID		7143	6614
HPRD ID		03589	02854
Ensembl ID		ENSG00000116147	ENSG00000088827
Uniprot IDs		A1L306 Q92752	Q9BZZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Dermatan Sulfate Biosynthetic Process Cell Adhesion Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Glycosaminoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Proteoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Pathogenesis Chondroitin Sulfate Metabolic Process Axonogenesis Nervous System Development Central Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Glycoprotein Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Glycoprotein Metabolic Process Neuron Development Neurogenesis Cell Morphogenesis Skeletal System Development Cell Development Neuron Differentiation Chemotaxis Cell Projection Organization Locomotion System Development Movement Of Cell Or Subcellular Component Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Multicellular Organismal Development Extracellular Matrix Disassembly Anatomical Structure Development Catabolic Process Carbohydrate Metabolic Process	Associative Learning Negative Regulation Of Cell-cell Adhesion Learning Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Cell Adhesion Negative Regulation Of Type IV Hypersensitivity Learning Or Memory Cognition Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Axon Regeneration Positive Regulation Of Transmission Of Nerve Impulse Single-organism Behavior Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Single Organismal Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Thymic T Cell Selection Negative Regulation Of Acute Inflammatory Response Negative Regulation Of T Cell Mediated Immunity Negative T Cell Selection Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Behavior Chemotaxis Neuron Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Histone H4 Acetylation Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Axon Regeneration Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Thymic T Cell Selection Positive Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Axon Extension Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Acetylation Response To Protozoan Exploration Behavior Cell Migration Cell Motility
Tagcloud ?		1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual	alternative biomarker ccr1 cd14 cluster clustering clusters complication cutaneous diffuse distinguished exclusively greatly hierarchical idiopathic ifn il13ra1 immunoassay lcssc messenger monocyte mononuclear mrc1 mx1 pah pbmc pbmcs ssc supervised
Tagcloud (Difference) ?		1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual	alternative biomarker ccr1 cd14 cluster clustering clusters complication cutaneous diffuse distinguished exclusively greatly hierarchical idiopathic ifn il13ra1 immunoassay lcssc messenger monocyte mononuclear mrc1 mx1 pah pbmc pbmcs ssc supervised
Tagcloud (Intersection) ?